Surfen dihydrochloride - ≥98%(HPLC) , CAS No.5424-37-3

CAS: 5424-37-3 Cat. No.: S286940 Formula: C₂₁H₂₂Cl₂N₆O Peso molecolare: 445.35 PubChem CID: 79472

GRADE & PURITY ≥98%(HPLC)

Synonyms

AKOS030527176 | EINECS 226-566-0 | Tox21_110013 | 1,3-Bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride | DTXSID1045083 | NSC 12155 | MFCD00051734 | Surfen dihydrochloride | Aminoquincarbamide dihydrochloride | Luminor Yellow Green 490RT | P2YT71SUIU |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Product Describtion:

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection.

Specifications

Sinonimi

AKOS030527176 | EINECS 226-566-0 | Tox21_110013 | 1,3-Bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride | DTXSID1045083 | NSC 12155 | MFCD00051734 | Surfen dihydrochloride | Aminoquincarbamide dihydrochloride | Luminor Yellow Green 490RT | P2YT71SUIU |

Specifiche e purezza

≥98%(HPLC)

Meccanismi biochimici e fisiologici

Heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachmentin vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%(HPLC)

Nomi e identificatori

Pubchem Sid

504755377

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504755377

Sorrisi canonici

CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N)N.Cl.Cl

IUPAC Name

1,3-bis(4-amino-2-methylquinolin-6-yl)urea;dihydrochloride

InChIKey

GKQYGRWQCWWSHN-UHFFFAOYSA-N

INCHI

1S/C21H20N6O.2ClH/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);2*1H

Isomeri SMILES

CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC4=C(C=C(N=C4C=C3)C)N)N.Cl.Cl

PubChem CID

79472

Peso molecolare

445.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Aminoquinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Aminoquinolines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: 4-aminoquinolines
• Alternative Parents: Methylpyridines Aminopyridines and derivatives Benzenoids Heteroaromatic compounds Ureas Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 4-aminoquinoline - Aminopyridine - Methylpyridine - Pyridine - Benzenoid - Heteroaromatic compound - Urea - Carbonic acid derivative - Azacycle - Organic oxygen compound - Hydrocarbon derivative - Hydrochloride - Organic nitrogen compound - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solvent:water, Max Conc. mg/mL: 8.91, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 8.91, Max Conc. mM: 20
• Sensibilità: light sensitive；Moisture sensitive.
• Peso molecolare: 445.300 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 444.123 Da
• Monoisotopic Mass: 444.123 Da
• Topological Polar Surface Area: 119.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 513.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Domande frequenti

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 5424-37-3, the molecular formula is C21H22Cl2N6O, and the molecular weight is 445.35 g/mol. InChIKey GKQYGRWQCWWSHN-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.