Syk-IN-4 - ≥98% , CAS No.S658845

CAS: S658845 Cat. No.: S658845 Formula: C₂₁H₂₅N₉O Peso molecolare: 419.48

QUALITÀ & PUREZZA ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC 50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

Appearance:Solid

IC50& Target:IC50: 0.31 nM (SYK)

In Vitro:Syk-IN-4 is a potent inhibitor of hERG with an IC 50 of 3.0 μM. Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI 50 s of 0.24 and 2.6 µM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for ref

In Vivo:Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1mg/kg) in male Hans Wistar rats. Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) follow

Biological Activity:Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC 50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

Specifiche

Specifiche e purezza

≥98%

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

CC1=NN(C=C1CN(C)C)C2=NC(NC3=CC=C(N(C)N=C4C(NC)=O)C4=C3)=NC=C2

Peso molecolare

419.48

Proprietà chimiche e fisiche

• Solubilità: DMSO : 62.5 mg/mL (148.99 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is S658845, the molecular formula is C21H25N9O, and the molecular weight is 419.48 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.