T807 - 10mM in DMSO , CAS No.1415379-56-4

CAS: 1415379-56-4 Cat. No.: T656719 Formula: C₁₆H₁₀FN₃ Peso molecolare: 263.27 Numero EC: 807-515-7 PubChem CID: 71059746

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

T807 a novel tau positron emission tomography (PET) tracer.

In Vitro

Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [ 18 F]T807 exhibits strong binding to PHF-tau positive human brain sections (K d =14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [ 18 F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [ 18 F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [ 18 F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[ 18 F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [ 18 F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

T807 a novel tau positron emission tomography (PET) tracer.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: C1=CC2=C(C=C1C3=CN=C(C=C3)F)NC4=C2C=NC=C4
• CAS alternativo: 1415379-56-4
• PubChem CID: 71059746
• Termini MeSH: (18)AV-1451;(18)F-flortaucipir;(18F)1451;(18F)AV-1451;(18F)flortaucipir;(18F)T807 compound;(F-18)-AV-1451;(F-18)T807;7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole;AV-1451;AV1451;F-18-AV-1451;flortaucipir;flortaucipir (18F);flortaucipir (F 18);flortaucip
• Peso molecolare: 263.27

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1415379-56-4, the molecular formula is C16H10FN3, and the molecular weight is 263.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.