Tazarotene - Moligand™, 10mM in DMSO , Retinoic acid receptor agonist, CAS No.118292-40-3, Retinoic acid receptor agonist

CAS: 118292-40-3 Cat. No.: T408686 Formula: C₂₁H₂₁NO₂S Peso molecolare: 351.46 Numero EC: 601-516-4 PubChem CID: 5381

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AGN190168 | 6-​[2-​(3,​4-​dihydro-​4,​4-​dimethyl-​2H-​1-​benzothiopyran-​6-​yl)​ethynyl]​-​3-​Pyridinecarboxylic acid ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
In vitro

Tazarotene causes ERK activation, RB tumor suppressor protein hypophosphorylation, G0 arrest, and myeloid differentiation in HL-60 human myeloblastic leukemia cells. Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective ligand. Tazarotene therapy regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. Tazarotene inhibits the proliferation of fibroblasts and synthesis of DNA and collagen. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. Tazarotene also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. Tazarotene causes growth suppression in retinoid-responsive breast cancer cell lines by up-regulating TIG3.

In vivo

Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in UV-treated Ptch1+/− mice. Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in ionizing radiation-treated Ptch1+/− mice.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinonimi

AGN190168 | 6-​[2-​(3,​4-​dihydro-​4,​4-​dimethyl-​2H-​1-​benzothiopyran-​6-​yl)​ethynyl]​-​3-​Pyridinecarboxylic acid ethyl ester

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST

Meccanismo d'azione

Retinoic acid receptor agonist

Proprietà del prodotto

• ALogP: 4.9

Nomi e identificatori

• Isomeri SMILES: CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
• WGK Germania: 3
• RTECS: US5675100
• PubChem CID: 5381
• Peso molecolare: 351.46
• Reaxy-Rn: 8159145

Obiettivi associati (umani)

RARG Tclin Retinoic acid receptor gamma (2 Activities)

Discover Target: RARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RARB Tclin Retinoic acid receptor beta (2 Activities)

Discover Target: RARB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RARA Tclin Retinoic acid receptor alpha (2 Activities)

Discover Target: RARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Punto di fusione (°C): 105 °C

Riferimenti

1. Yan Deng, Hao Cheng, Ji Zhu, Yue Jiang, Hongwu Sun, Guocheng Li, Jing Wei, Ruoyi Xue, Rang Feng, Jingwen Cao, Wenkang Yu, Yalan Wang, Mingqi Xu, Quanming Zou, Haibo Li.  (2025)  Tamibarotene-Loaded Nanoemulsion Incorporating Toll-like Receptor 2/6 Agonist as an Intramuscular Adjuvant System Enhances Gastrointestinal Mucosal Immunity.  ACS Nano,      [PMID:40376869] [10.1021/acsnano.5c00563]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 118292-40-3, the molecular formula is C21H21NO2S, and the molecular weight is 351.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.