TDI-011536 - ≥99% , CAS No.2687970-96-1

CAS: 2687970-96-1 Cat. No.: T646295 Formula: C₁₉H₁₆N₄O₂S Peso molecolare: 364.42

GRADE & PURITY ≥99%

Synonyms

TDI-011536 | HY-150042 | (Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | N-[3-benzyl-4-(hydroxymethyl)-1,3-thiazol-2-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | G70084 | SCHEMBL23727688 | SCHEMBL237

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration

In Vitro

TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of Müller glia in human retinal organoids. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: human retinal organoids Concentration: 3 µM Incubation Time: 24 h, 5 days Result: Supressed Yap phosphorylation and promoted Müller glia proliferation.

In Vivo

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs . TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection) . Dosage: 200 mg/kg Administration: Intraperitoneal injections; once. Result: Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day. Animal Model: Male 8-week-old mice (cryolesion model) . Dosage: 100 mg/kg Administration: Intraperitoneal injections; once daily for 2 or 3 days. Result: Promoted cardiomyocytes proliferation.

Form:Solid

IC50& Target:Lats kinase

Specifications

Sinonimi

TDI-011536 | HY-150042 | (Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | N-[3-benzyl-4-(hydroxymethyl)-1,3-thiazol-2-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | G70084 | SCHEMBL23727688 | SCHEMBL237

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥99%

Nomi e identificatori

Peso molecolare

364.42

Proprietà chimiche e fisiche

• Solubilità: DMSO : 125 mg/mL (343.01 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2687970-96-1, the molecular formula is C19H16N4O2S, and the molecular weight is 364.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.