TDI-10229 - 10mM in DMSO , CAS No.2810887-45-5

CAS: 2810887-45-5 Cat. No.: T655284 Formula: C₁₆H₁₆ClN₅ Peso molecolare: 313.78

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) . TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays ( IC 50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound

In Vitro

TDI-10229 exhibits good permeability with an IC 50 of 92 nM for human 4-4 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TDI-10229 (5 mg/kg; p.o.) treatment shows the C max , AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MouseDosage: 20 mg/kg Administration: P.o.(Pharmacokinetic Analysis) Result: The C max , AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.

IC50& Target:IC 50 : 195 nM (sAC)

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) . TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays ( IC 50 of 195 nM) and exhibits mouse pharmacokinetic properties suf

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Nomi e identificatori

• Peso molecolare: 313.78