Tenovin-1 - 10mM in DMSO , CAS No.380315-80-0

CAS: 380315-80-0 Cat. No.: T408399 Formula: C₂₀H₂₃N₃O₂S Peso molecolare: 369.48 PubChem CID: 1013376

GRADE & PURITY 10mM in DMSO

Synonyms

Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2 . Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH
In vitro

Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.

In vivo

Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
Cell Data

cell lines：Raw 264.7 cells

Concentrations：10 μM

Incubation Time：4 days

Powder Purity:≥99%

Specifications

Sinonimi

Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

PubChem CID

1013376

Peso molecolare

369.48

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 380315-80-0, the molecular formula is C20H23N3O2S, and the molecular weight is 369.48 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.