Tesevatinib - Moligand™, 10 mM in DMSO , CAS No.781613-23-8

CAS: 781613-23-8 Cat. No.: T1496249 Molecular Weight: 491.39 PubChem CID: 10458325

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor ( EGFR ). Tesevatinib significantly reduces cellular viability, with IC 50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 ( IC 50 =16.1 nM), VEGFR2 ( IC 50 =1.5 nM), and Src ( IC 50 =10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• ALogP: 5.8

Names and Identifiers

• Isomeric SMILES: CN1C[C@H]2CC(C[C@H]2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
• Alternate CAS: 781613-23-8
• PubChem CID: 10458325
• MeSH Entry Terms: EXEL-7647;N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta(c)pyrrol-5-yl)methoxy)-4-quinazolinamine;tesevatinib;XL-647;XL647
• Molecular Weight: 491.39