Tezacaftor (VX-661) - Moligand™, 10mM in DMSO , Cystic fibrosis transmembrane conductance regulator positive modulator, CAS No.1152311-62-0, Cystic fibrosis transmembrane conductance regulator positive modulator

CAS: 1152311-62-0 Cat. No.: T407910 Formula: C₂₆H₂₇F₃N₂O₆ Peso molecolare: 520.5 Numero EC: 810-780-1 PubChem CID: 46199646

QUALITÀ & PUREZZA Moligand™, 10mM in DMSO

Synonyms

Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Tezacaftor (VX-661) Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
In vitro

VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

In vivo

Cell Data

cell lines：TERT/LT/ST/RASV12\xa0cells\xa0

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Tezacaftor\xa0(VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

POSITIVE MODULATOR

Meccanismo d'azione

Cystic fibrosis transmembrane conductance regulator positive modulator

Proprietà del prodotto

ALogP

2.9

Nomi e identificatori

Isomeri SMILES

CC(C)(CO)C1=CC2=CC(=C(C=C2N1C[C@H](CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F

PubChem CID

46199646

Peso molecolare

520.5

Obiettivi associati (umani)

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (3 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1152311-62-0, the molecular formula is C26H27F3N2O6, and the molecular weight is 520.5 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.