Thiocarbohydrazide - ≥98% , CAS No.2231-57-4

CAS: 2231-57-4 Cat. No.: T303106 Molecular Weight: 106.15 EC Number: 218-769-8 PubChem CID: 2724189
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
Thiocarbohydrazide, 98% | 1IZ2H82NWU | STR03786 | Thiocarbohydrazide, purum p.a., for electron microscopy, >=99.0% (N) | Carbonothioicdihydrazide | STK141127 | 1,3-DIAMINO-2-THIOUREA | T1136 | AKOS001027231 | NCGC00249036-01 | USAF EK-7372 | Hydrazinecarb
Storage
Store at 2-8°C,Argon charged,Desiccated
Shipped In
Wet ice
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Status
Price
Qty
5g
T303106-5g
3
$9.90
25g
T303106-25g
2
$13.90
100g
T303106-100g
10
$24.90
500g
T303106-500g
1
$99.90
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 40 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Thiocarbohydrazide is used in electron microscopy to produce electron-opaque deposits for ultra structural analysis. It is used in the synthesis of oxazine grass ketones.

Specifications

Synonyms
Thiocarbohydrazide, 98% | 1IZ2H82NWU | STR03786 | Thiocarbohydrazide, purum p.a., for electron microscopy, >=99.0% (N) | Carbonothioicdihydrazide | STK141127 | 1, 3-DIAMINO-2-THIOUREA | T1136 | AKOS001027231 | NCGC00249036-01 | USAF EK-7372 | Hydrazinecarb
Specifications & Purity
≥98%
Storage
Store at 2-8°C, Argon charged, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid504760861
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504760861
Canonical SmilesC(=S)(NN)NN
IUPAC Name1,3-diaminothiourea
InChIKeyLJTFFORYSFGNCT-UHFFFAOYSA-N
INCHI1S/CH6N4S/c2-4-1(6)5-3/h2-3H2,(H2,4,5,6)
Isomeric SMILES C(=S)(NN)NN
PubChem CID 2724189
UN Number 2811
Packing Group I
Molecular Weight 106.15

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganosulfur compounds
ClassNot available
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentOrganosulfur compounds
Alternative Parents Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as organosulfur compounds. These are organic compounds containing a carbon-sulfur bond.
External Descriptors thiocarbonyl compound
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
E2305323Certificate of AnalysisFeb 26, 2026 T303106
E2515635Certificate of AnalysisMay 07, 2025 T303106
E2515636Certificate of AnalysisMay 07, 2025 T303106
E2515637Certificate of AnalysisMay 07, 2025 T303106
E2515638Certificate of AnalysisMay 07, 2025 T303106
L2107130Certificate of AnalysisSep 20, 2024 T303106
L2107131Certificate of AnalysisSep 20, 2024 T303106
L2107153Certificate of AnalysisSep 20, 2024 T303106
E2507537Certificate of AnalysisJun 18, 2024 T303106
E2507538Certificate of AnalysisJun 18, 2024 T303106
E2507536Certificate of AnalysisJun 18, 2024 T303106
E2507534Certificate of AnalysisJun 18, 2024 T303106
E2507535Certificate of AnalysisJun 18, 2024 T303106
D2129233Certificate of AnalysisFeb 26, 2024 T303106
D2129234Certificate of AnalysisFeb 26, 2024 T303106

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Chemical and Physical Properties
SolubilityVery slightly soluble (0.5g/100g, 25°C). Insoluble in ether.
SensitivityAir sensitive;Light sensitive;Heat sensitive
Melt Point(°C)171-174°C dec. (Lit.)
Molecular Weight106.150 g/mol
XLogP3-1.000
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass106.031 Da
Monoisotopic Mass106.031 Da
Topological Polar Surface Area108.000 Ų
Heavy Atom Count6
Formal Charge0
Complexity45.500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Li Fu, Zerui Liu, Pengjie Dong, Yingshu Guo.  (2023)  Electrochemiluminescence Mechanistic Insights of CuInS2/ZnS Nanocrystals with Hydrazine Compounds as Co-reactants.  Journal of Physical Chemistry C,      [PMID:] [10.1021/acs.jpcc.3c06277]
2. Zhangzhen Wu, Zhi Guo, Dazhuang Dong, Feiyan Wu, Jie Li, Xue Yang.  (2023)  Distinguishable adsorption interaction of virgin and biofilm covered polyethylene and polylactic acid for antibiotics.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2023.111143]
3. Enas A. Imam, Ahmed I Hashem, Ahmad A. Tolba, Mohammad G. Mahfouz, Ibrahim El-Tantawy El-Sayed, Hamada B. Hawash, Rana R. Neiber, Hamed I. Mira, Ahmed A. Galhoum, Eric Guibal.  (2023)  Aminophosphonate CuO nanocomposites for uranium(VI) removal: Sorption performance and mechanistic study.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2023.124466]
4. Guo Huilin, Yu Tingting, Zhao Lei, Qian Jun, Yu Jiahe, Zhang Yu, Teng Yongyue, Zhu Chunshui, Yang Tao, Chen Wenbin, Gong Picheng, Jiang Cuishuang, Gao Changfei, Yang Bing, Yang Chenyu.  (2023)  Performance study of g-C3N4/carbon black/BiOBr@Ti3C2/MoS2 photocatalytic fuel cell for the synergistic degradation of different types of pollutants.  Carbon Letters,  33  (3): (847-862).  [PMID:] [10.1007/s42823-023-00465-8]
5. Jia-Qi Li, Qing-Meng Zhao, Yong-Dong Zhou, Zong-Yan Zhao.  (2023)  CuGaO2/TiO2 heterostructure nanosheets: Synthesis, enhanced photocatalytic performance, and underlying mechanism.  JOURNAL OF THE AMERICAN CERAMIC SOCIETY,  106  (5): (3009-3023).  [PMID:] [10.1111/jace.18983]
6. Qingfeng Cui, Xinyue Gu, Yue Zhao, Kezhen Qi, Ya Yan.  (2023)  S-scheme CuInS2/ZnS heterojunctions for the visible light-driven photocatalytic degradation of tetracycline antibiotic drugs.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2023.104679]
7. Tiantian Lv, Yan Zhao, Sai Li, Lei Zhang, Fan Wu, Zongxing Liu, Chunna Yu, Chang Zhao, Guangjian Xing.  (2022)  One-pot synthesis of a CaBi2O4/graphene hybrid aerogel as a high-efficiency visible-light-driven photocatalyst.  JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS,      [PMID:] [10.1016/j.jpcs.2022.111164]
8. Tingting Tian, Xinfeng Zhu, Zhongxian Song, Xindong Li, Jinhui Zhang, Yanli Mao, Junfeng Wu, Wei Zhang, Chaohai Wang.  (2022)  Large-Scale Synthesis of Iron Ore@Biomass Derived ESBC to Degrade Tetracycline Hydrochloride for Heterogeneous Persulfate Activation.  Catalysts,  12  (11): (1345).  [PMID:] [10.3390/catal12111345]
9. Yi Wang, Shaoqi Zhang, Yuxiang Yan, Hengdong Ren, Jian Chen, Lizhe Liu, Xinglong Wu.  (2022)  Multi-anions-coupled electronic states in Cl−-doped BiOBr induce highly efficient decomposition of tetracycline hydrochloride.  MATERIALS RESEARCH BULLETIN,      [PMID:] [10.1016/j.materresbull.2022.112045]
10. Shan Junyue, Wu Xianliang, Li Caifang, Hu Jiwei, Zhang Zhenming, Liu Huijuan, Xia Pinhua, Huang Xianfei.  (2022)  Photocatalytic degradation of tetracycline hydrochloride by a Fe3O4/g-C3N4/rGO magnetic nanocomposite mechanism: modeling and optimization.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (3): (8098-8109).  [PMID:36050555] [10.1007/s11356-022-22770-x]
11. Min Zhang, Muhammad Arif, Yunyuan Dong, Xiaobin Chen, Xiaoheng Liu.  (2022)  Z-scheme TiO2−x@ZnIn2S4 architectures with oxygen vacancies-mediated electron transfer for enhanced catalytic activity towards degradation of persistent antibiotics.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.129530]
12. Yongtao Xue, Zengyue Chen, Zhansheng Wu, Fei Tian, Bing Yu.  (2021)  Hierarchical construction of a new Z-scheme Bi/BiVO4-CdS heterojunction for enhanced visible-light photocatalytic degradation of tetracycline hydrochloride.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2021.119152]
13. Wenning Yang, Jia Li, Yangsai Lyu, Xiaohui Yan, Ping Yang, Min Zuo.  (2021)  Bioinspired 3D hierarchical BSA-NiCo2O4@MnO2/C multifunctional micromotors for simultaneous spectrophotometric determination of enzyme activity and pollutant removal.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2021.127294]
14. Mi Wu, Wen Liu, Jinrong Yao, Zhengzhong Shao, Xin Chen.  (2020)  Silk microfibrous mats with long-lasting antimicrobial function.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,      [PMID:] [10.1016/j.jmst.2020.02.060]
15. Guohai Yang, Daqing Zhang, Cheng Wang, Hong Liu, Lulu Qu, Haitao Li.  (2019)  A Novel Nanocomposite Membrane Combining BN Nanosheets and GO for Effective Removal of Antibiotic in Water.  Nanomaterials,  (3): (386).  [PMID:30845787] [10.3390/nano9030386]
16. Mao Xiqiang, Zou Sujing, Lu Xue, Li Shaoyi, Wu Lei, Li Jun, Yang Jian, Fan Ximei.  (2025)  Bi2O3 Modified Floatable Hollow Glass Microspheres Supported TiO2 to Construct II-Scheme Heterojunction for Photocatalytic Degradation of Tetracycline Hydrochloride.  KOREAN JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1007/s11814-025-00390-8]
17. Jianke Tang, Qiaoling Li, Rongqian Meng, Yanfeng Xue, Shengjian Zhang, Shengjuan Shao.  (2024)  Facile Preparation and Enhanced Visible Light Photocatalytic Performance of AgI/Ag3PO4/WO3·H2O Heterojunction Photocatalysts.  Asia-Pacific Journal of Chemical Engineering,      [PMID:] [10.1002/apj.3193]
18. Ying Zeng, Sitong Liu, Guopeng Zhu, Xiutao Yang, Hongwen Yu.  (2024)  Fe(Ⅲ)-doped ZnIn2S4-modified graphene oxide in-situ for the degradation of tetracycline hydrochloride in simulated sunlight.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2024.135053]
19. Min Zhou, Dan Zheng, Kun Yang, Lifang Hu, Zhongbiao Zhang.  (2025)  Insight into the photothermal Fenton-like degradation of tetracycline hydrochloride by cu/Ce modified Na-X zeolites: Performance, mechanism, and degradation pathways.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2025.107482]
20. Xixi Di, Xia Zeng, Xiaoyu Zhang, Tian Tang, Zuoping Zhao, Wei Wang, Zhifeng Liu, Lingxia Jin, Xiaohui Ji, Xianzhao Shao.  (2024)  Nitrogen-phosphorus codoped biochar prepared from tannic acid for degradation of trace antibiotics in wastewater.  ENVIRONMENTAL RESEARCH,      [PMID:39672491] [10.1016/j.envres.2024.120589]
21. Liang-Zhi Qiao, Yuan-Zhi Tan, Shan-Jing Yao, Dong-Qiang Lin.  (2024)  Pore structure reconstruction to reveal the adsorption capacity limitation of current oligo-dT resins and guide new resin design.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39490193] [10.1016/j.chroma.2024.465454]
22. Hailong Fu, Xue Song, Yongde Liu, Jie Zhang, Jihong Zhao, Feiyue Wang, Zeying Zhang, Zengchen Su, Han Zhang.  (2024)  Preparation and characterization of a novel activated carbon from wheat dust and its adsorption mechanism for tetracycline hydrochloride.  Particuology,      [PMID:] [10.1016/j.partic.2024.11.017]
23. Xiaolai Zhang, Fangli Li, Jingbo Chao, Zhicai Li, Guimin Zhang, Lihai Zhai, Ligang Hu, Heping Jiao, Zhenhua Wang.  (2024)  Simultaneous enrichment and speciation of lead and mercury by magnetic solid-phase extraction coupled to HPLC-ICP-MS based on magnetic hydrazine-linked covalent organic frameworks.  ANALYTICA CHIMICA ACTA,      [PMID:38719403] [10.1016/j.aca.2024.342622]
24. Zhineng Dai, Wenqi Zhang, Jiazhong Li, Yicheng Wu, Haiyan Fu.  (2024)  Study on prediction model of TCH degradation by three -dimensional electrocatalysis based on XGBoost and MLP.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2024.106420]
25. Xuyang Hu, Lihui Huang, Ting Sun, Zhenhui Gao, Zhengjun Qu.  (2024)  TiO2-loading modification on graphene aerogel particle electrode for electrochemical oxidation of TCH wastewater with low electrolyte concentration: Performance and mechanism.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2024.118268]
26. Yang Yangyang, Chen Qi, Wang Xiao, Hou Jun, Ren Lingxiao, Fan Xiulei, Liu Qiang, Liu Jiaqiang, Xu Ke, You Guoxiang.  (2025)  Insights into the Properties and Adsorption–desorption Behaviors of Aged Microplastics with Different Colors.  WATER AIR AND SOIL POLLUTION,  236  (11): (1-17).  [PMID:] [10.1007/s11270-025-08395-z]
27. Nannan Zhang, Rui Hou, Yaohan Chen, Xue Wang, Shenghai Li, Suobo Zhang.  (2025)  Dual-Network Topology Engineering via Dynamic Cross-Linking for Advanced Cathode Binders.  ACS Applied Materials & Interfaces,      [PMID:40932056] [10.1021/acsami.5c12397]
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32. Shihui Zhang, Xu Zhang, Wanting Shi, Weiyan He, Caihong Li, Xiaojing Wang.  (2025)  The study on the construction of S-scheme g-C3N4/MIL-101 heterojunctions through interface and built-in electric field modulation and their photocatalytic degradation performance of tetracycline.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2025.142195]
33. Conghao Liu, Yang Yang, Runzhi Li, Xiaoqing Zhang, Dionisio Zaldivar Silva, Yuefeng Zhao, Ruizhuo Ouyang, Yuqing Miao, Baolin Liu, Shuang Zhou.  (2025)  Enhanced Anticancer Activity of Novel Bi (III)-Thiosemicarbazone Complexes Against Lung Cancer.  APPLIED ORGANOMETALLIC CHEMISTRY,  39  (7): (e70249).  [PMID:] [10.1002/aoc.70249]
34. Zheng Xu, Huan Liang, Huali Zhang, Hai Liu, Xufu Tan, Yanting Yang.  (2025)  Heterogeneous activation of peroxymonosulfate by sludge ceramsite for the degradation of tetracycline hydrochloride.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2025.106231]
35. Shuyan Qi, Yang Wang, Shanqiang Wu, Haiyang Li, Xu hu.  (2025)  Study on the mechanism of Bi2WO6/ NixMo1-xS2 heterojunction photocatalysis for efficient degradation of TCH.  MATERIALS CHEMISTRY AND PHYSICS,      [PMID:] [10.1016/j.matchemphys.2025.131796]
36. Zilu Li, Xuefei Chen, Hou-Yong Yu, Chao Wu, Somia Yassin Hussain Abdalkarim, Yunfei Shen, Guojun Jin, Jia-Fu Zhu.  (2026)  Sustainable hydrogen peroxide oxidation of carboxylated cellulose nanocrystals: efficient modulation of carboxyl content, hydrophilicity, and particle size for tablet formulation and drug release.  Nanoscale,      [PMID:41636520] [10.1039/D5NR04293C]
37. Xixi Di, Xia Zeng, Shujun Meng, Tian Tang, Wei Wang, Hanghang Zhao, Xiaohui Ji, Lingxia Jin, Chao Duan, Xianzhao Shao.  (2026)  Antibiotic degradation via synergistic oxidation: Zero - valent iron enhanced carbon - based catalyst activating peroxymonosulfate.  Journal of Environmental Chemical Engineering,  14  (2): (121737).  [PMID:] [10.1016/j.jece.2026.121737]
38. Yunchang Fan, Jingjing Chen, Miao Li, Sheli Zhang, Xinjia Wei, Haibao Zhu.  (2026)  Ionic liquid-functionalized copper oxide for efficient photocatalytic degradation of tetracycline hydrochloride.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2026.166256]
39. Hao Li, Minru Su, Chen Shi, Rouyi Wang, Anqi Xu, Xiaolan Shen.  (2026)  Three-dimensional electrochemical process using Fe-based reduced graphene oxide hydrogel particle electrodes for peroxydisulfate activation and improved tetracycline hydrochloride degradation.  Desalination and Water Treatment,      [PMID:] [10.1016/j.dwt.2026.101697]
40. Qianhao Zhao, Yaping Wang, Yongyuan Yang, Longhui Nie, Naixin Kang.  (2026)  One-step synthesized Zn-doped UiO-66 for effective removal of tetracycline hydrochloride from wastewater.  NEW JOURNAL OF CHEMISTRY,  50  (13): (5530-5540).  [PMID:] [10.1039/D5NJ04714E]
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