Tinidazole - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.19387-91-8, DNA inhibitor

CAS: 19387-91-8 Cat. No.: T407955 Formula: C₈H₁₃N₃O₄S Peso molecolare: 247.27 Numero EC: 243-014-4 PubChem CID: 5479

QUALITÀ & PUREZZA Moligand™, 10mM in DMSO

Synonyms

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Tinidazole (CP12574) is an anti-parasitic drug.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

DNA inhibitor

Nomi e identificatori

Isomeri SMILES

CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

RTECS

NI6255000

PubChem CID

5479

Peso molecolare

247.27

Reaxy-Rn

618182

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL (162.21 mM); Water: Insoluble; Ethanol: Insoluble
• Punto di fusione (°C): 129 °C