TJ-M2010-5 - Moligand™,≥99% , CAS No.1357471-57-8

CAS: 1357471-57-8 Cat. No.: T646234 Formula: C₂₃H₂₆N₄OS Peso molecolare: 406.54

GRADE & PURITY Moligand™, ≥99%

Synonyms

3-(4-Benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl)propanamide

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Panoramica

TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI) .

In Vitro

TJ-M2010-5 (40 μM) inhibits MyD88 homodimerization in transfected HEK293 cells in a concentration-dependent manner and suppresses MyD88 signaling in LPS (100 ng/mL)-responsive RAW 264.7 cells in vitro. ?\nTJ-M2010-5 (5-30 μM) prevents B cell proliferation and induces B cells apoptosis after stimulation with R848 (500 ng/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Purified B cells Concentration: 0 μM, 5 μM, 10 μM, 20 μM and 30 μM Incubation Time: 48 hours Result: Inhibited the viability of B cells with or without the stimulation of CD40L.

In Vivo

TJ-M2010-5 treatment statistically significantly reduces AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, results in 0% mortality of treated mice, decreases cell proliferation, and increased apoptosis in colon tissue in a 10-week CAC mouse model . ?\nTJ-M2010-5 statistically significantly decreases TNF-α, IL-6, G-CSF, MIP-1β, IL-11, IL-17A, IL-22, and IL-23 serum concentrations in mice at both two and seven weeks postinduction, as well as TGF-β1 serum levels at seven weeks postinduction . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BalB/c mice (6–8 weeks old) Dosage: 50 mg/kg Administration: Treated i.p. daily beginning two days before the first dextran sodium sulfate (DSS) administration throughout a 10-week observation period. Result: Significantly prevented inflammation/CAC-related body weight loss and mortality (0% vs 53% in the control group).

Form:Solid

Specifications

Sinonimi

3-(4-Benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl)propanamide

Specifiche e purezza

Moligand™,≥99%

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light,Argon charged

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Purezza

≥99%

Nomi e identificatori

Peso molecolare

406.54

Proprietà chimiche e fisiche

• Solubilità: DMSO : 100 mg/mL (245.98 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1357471-57-8, the molecular formula is C23H26N4OS, and the molecular weight is 406.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.