TLK117 - Moligand™,10mM in DMSO , CAS No.152684-53-2

CAS: 152684-53-2 Cat. No.: T655572 Formula: C₂₃H₂₇N₃O₆S Peso molecolare: 473.54 PubChem CID: 444051

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K i of 0.56 μM.

In Vitro

TLK117 is the most specific GSTP inhibitor to date, with a binding affinity greater than GSH itself and a selectivity for GSTP over 50-fold greater than the GSTM and GSTA classes (K i =0.4 μM). TER 117 is developed as a GST P1-1 isoenzyme inhibitor to circumvent the indicated contribution of GST P1-1 to drug resistance of tumor cells. To facilitate the cellular uptake of TER 117, it is delivered as a diethyl ester (TER 117 DEE, also called TER 199). TER 117 is found to be a competitive inhibitor of both GST P1-1 and glyoxalase I. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oropharyngeal administration of the GSTP inhibitor, TLK117, at a time when fibrosis is already apparent, attenuated bleomycin- and AdTGFβ-induced remodeling, α-SMA, caspase activation, FAS S-glutathionylation, and total protein S-glutathionylation. Four hours after administration of 50 mg/kg TLK117, GSTP activity is strongly decreased and remains decreased by about 60% for at least 24 hours. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 0.4 μM, 0.56 μM (glyoxalase I)

Specifications

Specifiche e purezza

Moligand™,10mM in DMSO

Meccanismi biochimici e fisiologici

TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K i of 0.56 μM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nomi e identificatori

Isomeri SMILES

C1=CC=C(C=C1)CSC[C@@H](C(=O)N[C@H](C2=CC=CC=C2)C(=O)O)NC(=O)CC[C@@H](C(=O)O)N

CAS alternativo

152684-53-2

PubChem CID

444051

Termini MeSH

ezatiotsat;gamma-Glu-S-BzCys-PhGly diethyl ester;gamma-glutamyl-S-(benzyl)cysteinyl-phenylglycine diethyl ester;T.199;Telintra;TER 199;TER-199;TLK 117;TLK 199;TLK-117;TLK-199;TLK117;TLK199

Peso molecolare

473.54

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 152684-53-2, the molecular formula is C23H27N3O6S, and the molecular weight is 473.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.