Tolfenamic Acid - Moligand™, 10mM in DMSO , Inhibitor of AKR1C3, CAS No.13710-19-5, Inhibitor of AKR1C3

CAS: 13710-19-5 Cat. No.: T407845 Formula: C₁₄H₁₂ClNO₂ Peso molecolare: 261.7 Numero EC: 237-264-3 PubChem CID: 610479

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Tolfenamic Acid is aCOX-2inhibitor withIC50of 0.2 μM.
In vitro

In vivo

Cell Data

cell lines：RF/MT-2 strains

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinonimi

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of AKR1C3

Nomi e identificatori

• Isomeri SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
• WGK Germania: 3
• RTECS: CB2687500
• PubChem CID: 610479
• Peso molecolare: 261.7
• Reaxy-Rn: 657821

Obiettivi associati (umani)

TTR Tclin Transthyretin (1 Activities)

Discover Target: TTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Discover Target: AKR1C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 62 mg/mL (186.25 mM)
• Punto di fusione (°C): 209-214°C

Riferimenti

1. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang.  (2020)  A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2020.1740178]

2. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu.  (2019)  Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use.  CRYSTENGCOMM,  21  (35): (5284-5291).  [PMID:] [10.1039/C9CE00781D]

3. Xue Shu-Wen, Li Jing, Xu Li.  (2017)  Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (12): (3103-3113).  [PMID:28224244] [10.1007/s00216-017-0251-8]

4. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]