TPP-1 - ≥99% , CAS No.2426685-25-6

CAS: 2426685-25-6 Cat. No.: T646515 Formula: C₁₀₇H₁₅₀N₃₄O₃₂S₂ Peso molecolare: 2488.67

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity ( K D =95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.

In Vitro

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1. TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5 to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector Dosage: 4 mg/kg Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32days Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.

Form:Solid

Specifications

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction . TPP-1 binds specifically to PD-L1 with a high affinity ( K D =95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.

Condizioni di conservazione di stoccaggio

Desiccated,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥99%

Nomi e identificatori

• Peso molecolare: 2488.67

Proprietà chimiche e fisiche

• Solubilità: H2O : 50 mg/mL (20.09 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2426685-25-6, the molecular formula is C107H150N34O32S2, and the molecular weight is 2488.67 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.