Triciferol - ≥98% , CAS No.957214-00-5

CAS: 957214-00-5 Cat. No.: T648621 Formula: C₂₆H₃₉NO₄ Peso molecolare: 429.59

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Panoramica

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR ( IC 50 =87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

In Vitro

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells. Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MDA-MB231 breast cancer cells Concentration: 0-10000 nM Incubation Time: 0-72 hours Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.

Form:Solid

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR ( IC 50 =87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induce

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light,Argon charged

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C[C@@H](O)C[C@H](O)C/3)/C=C(C)/C=C/C(NO)=O
• Peso molecolare: 429.59

Proprietà chimiche e fisiche

• Solubilità: DMSO : 100 mg/mL (232.78 mM; Need ultrasonic)