TRx0237 (LMTX) mesylate - ≥98% , CAS No.1236208-20-0

CAS: 1236208-20-0 Cat. No.: T413826 Formula: C₁₈H₂₇N₃O₆S₃ Peso molecolare: 477.62 Numero EC: 811-371-0 PubChem CID: 60150609

GRADE & PURITY ≥98%

Synonyms

TRx0237 mesylate;Methylene blue leuco base mesylate | LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE) | Leucomethylene blue Mesylate | N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diaminedimethanesulfonate | MS-28864 | Leucomethylene blue (Mesylate) |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

TRx0237 (LMTX) mesylate TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

Targets

tau protein aggregation

In vitro

TRx 0237 (LMTX™) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer\'s disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer\'s Disease brain tissues at the concentration at 0.16 μM.

In vivo

TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66.

Specifications

Sinonimi

TRx0237 mesylate;Methylene blue leuco base mesylate | LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE) | Leucomethylene blue Mesylate | N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diaminedimethanesulfonate | MS-28864 | Leucomethylene blue (Mesylate) |

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

Pubchem Sid

504771791

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504771791

Sorrisi canonici

CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O

IUPAC Name

methanesulfonic acid;3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine

InChIKey

SPCMQFLNOVTUBM-UHFFFAOYSA-N

INCHI

1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)

Isomeri SMILES

CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O

PubChem CID

60150609

Peso molecolare

477.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzothiazines
      • Subclass Phenothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzothiazines
• Subclass: Phenothiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenothiazines
• Alternative Parents: Diarylthioethers Tertiary alkylarylamines Primary aromatic amines Benzenoids 1,4-thiazines Sulfonyls Organosulfonic acids Alkanesulfonic acids Secondary amines Azacyclic compounds Organic zwitterions Organic oxides Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Phenothiazine - Diarylthioether - Tertiary aliphatic/aromatic amine - Aryl thioether - Primary aromatic amine - Para-thiazine - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Tertiary amine - Azacycle - Secondary amine - Thioether - Organonitrogen compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organosulfur compound - Organic zwitterion - Amine - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (non umani)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 95 mg/mL (198.9 mM); Water: 95 mg/mL (198.9 mM); Ethanol: Insoluble
• Peso molecolare: 477.600 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 2
• Exact Mass: 477.106 Da
• Monoisotopic Mass: 477.106 Da
• Topological Polar Surface Area: 169.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 396.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1236208-20-0, the molecular formula is C18H27N3O6S3, and the molecular weight is 477.62 g/mol. InChIKey SPCMQFLNOVTUBM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.