QUALITÀ & PUREZZAMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
Moligand™ Moligand™ per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.
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Stoccaggio e spedizione
Room temperature Spedizione . Consultare il COA specifico del lotto per le specifiche esatte.
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Documenti di qualità
SDS, COA, scheda tecnica e scheda delle specifiche disponibili per il download. COA specifico del lotto accessibile tramite ricerca per numero di lotto.
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Prova documentale
Citato in 0 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Calcolatori di soluzioni
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Recensioni
Recensioni dei clienti
Application Protocols
Manufacturer-tested applications and conditions: Not specified for this item.
General assay setup guidance for small-molecule ligands (not item-specific)
Stock solutions: Prepare at 10–50 mM in anhydrous DMSO; vortex, sonicate if needed; filter if particulate persists and the compound is filter-stable.
Dose–response: 8–12 point serial dilutions (1:2 or 1:3) spanning at least two orders of magnitude around the expected potency. Maintain constant final solvent across wells.
Controls: Include positive/negative controls, vehicle controls, and, where appropriate, detergent controls to diagnose aggregation.
Data quality: Track Z′-factor, signal window, and assay CV. Confirm hits with fresh aliquots and an orthogonal assay.
Note: For any cell-based work, confirm that the final DMSO is within the tolerance of your cell line, and verify compound stability in culture media over the assay timeframe.
Biological Roles
Item-specific biological function/target: Not specified for this item; no target annotation or MoA is provided in the Product Data.
General considerations for small-molecule ligands (not a claim for this item)
Small molecules can act as enzyme modulators, receptor agonists/antagonists, ion channel blockers, or pathway probes, depending on their structure and context.
Before inferring biological roles, retrieve the definitive structure (via CAS/CID) and screen across a focused panel relevant to your research area. Confirm on-target effects with orthogonal assays and counter-screens to exclude assay artifacts.
Assess physicochemical liabilities that confound interpretation (aggregation, redox cycling, metal chelation, fluorescence/absorbance interference). Employ detergent tests, light/dark controls, and redox-quenching conditions as appropriate.
Data integrity
Record batch/lot identifiers and maintain full chain-of-custody. Reconfirm identity after long storage or if biological readouts drift.
Reminder: For research use only. No clinical or diagnostic use is implied.
Buffer Applications
Not typically applicable. UCCF-339 is a small-molecule screening ligand rather than a buffering agent. It does not form a defined buffer system in the absence of known acid/base functionalities.
Practical note
When preparing assay media, use established buffers (e.g., PBS, HEPES, Tris) validated for your target biology. Dissolve UCCF-339 stocks separately (commonly in DMSO) and add to buffered systems at controlled final solvent percentages.
Verify that the chosen buffer does not chemically react with the compound’s functional groups once those are confirmed from the structure (e.g., avoid primary amine buffers if aldehyde-bearing compounds are suspected).
Green Alternatives
Context: For screening ligands, the principal environmental impact often arises from solvent use rather than the microgram-to-milligram quantities of the compound itself.
Greener solvent strategies (general guidance)
Prefer aqueous buffers with minimal DMSO where feasible; validate activity across 0.1–0.5% DMSO to reduce solvent load.
Replace DMF/DMAC/NMP in any preparative steps with safer alternatives (e.g., Cyrene, propylene carbonate) when solubility permits—if such steps are part of your in-house reformatting.
For cleaning and prep, use ethanol or isopropanol over chlorinated solvents.
Illustrative comparison (general; not item-specific)
DMSO vs 2-MeTHF: DMSO is favored for stock solutions (miscible with water, low volatility); 2-MeTHF is a greener alternative to THF for synthetic steps but is rarely used for bioassay stock solutions.
Ethanol vs acetonitrile: Ethanol offers better safety/greenness but lower solvency; ACN is common for LC yet more hazardous.
Operational tips
Miniaturize assays (384–1536 well) to reduce solvent and compound usage.
Implement solvent recycling for LC mobile phases when compliance allows.
Note: No compound-specific green metrics can be provided without a confirmed structure; consult your institutional green chemistry guidelines for process-level improvements.
Pharmaceutical Uses
No pharmacopeial or excipient role is specified for this item. UCCF-339 is provided for research use only and is intended as a small-molecule ligand for discovery and in vitro experimentation.
General development-context notes (not specific to this item)
In early discovery, such ligands may serve as tool compounds for target validation, hit confirmation, and mechanism-of-action studies.
If progression toward preclinical formulation is contemplated, determine salt form, polymorph, and stability profile; none of these attributes are provided here and must be established experimentally.
Regulatory status: Not specified; not intended for human or veterinary use.
Manufacturing/analytical considerations
Establish potency, purity, and identity specifications aligned with your internal quality system. Implement stability-indicating methods (LC–MS/UPLC) and document storage conditions.
Reminder: This product is for research use only and is not for drug, diagnostic, or clinical applications.
Physical Properties
Item-specific specifications
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
Melting point (MP): Not specified for this item; refer to CoA/Spec Sheet.
Boiling point (BP): Not specified for this item; refer to CoA/Spec Sheet.
Density: Not specified for this item; refer to CoA/Spec Sheet.
Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
Solubility: Not specified for this item; refer to CoA/Spec Sheet.
General laboratory guidance (literature/practice; not item-specific)
For uncharacterized screening ligands, initial dissolution in anhydrous DMSO at 10–50 mM is common, followed by dilution into assay buffer. Assess clarity and precipitation upon aqueous dilution.
If the compound proves lipophilic (logP >2, literature), consider co-solvents (0.1–1% DMSO in buffer) or surfactants (0.01–0.05% Tween-20) compatible with your assay.
Determine UV-Vis characteristics empirically for concentration by absorbance; many aromatic small molecules exhibit bands in the 200–350 nm region, but verify experimentally.
Notes
Do not treat any of the above as specifications for this catalog item. Establish working properties by small-scale pre-tests and consult the CoA/SDS for authoritative values.
Quality and Grades
Grade information
Grade/Purity: Moligand™ (as provided).
What Moligand™ implies (general description; not a specification)
Moligand-grade items are supplied as small-molecule ligands intended for discovery screening, target validation, and SAR exploration. Focus is on suitability for biochemical/cell-based assays rather than synthetic reagent specifications.
Typical expectations for such screening ligands include: defined identity (CAS/CID/structure), assay-ready purity suitable for in vitro testing, and compatibility with common stock-solution practices (e.g., DMSO). Exact purity thresholds, residual solvents, and metal/anion limits are product-specific and must be verified on the CoA/Spec Sheet.
Item-specific notes
Reported storage condition: Room temperature.
Stabilizers, residual solvent profile, water/peroxide/metal limits, and UV cutoff: Not specified for this item; refer to CoA/Spec Sheet.
Best practices
Request and archive CoA/SDS for batch traceability.
For quantitative biology/biophysics, confirm purity by orthogonal methods (HPLC-UV/ELSD, LC–MS) and verify salt form/hydration as they impact concentration calculations.
Reaction and Applications
Scope: UCCF-339 is offered as a Moligand-grade small molecule intended for research screening rather than as a synthetic reagent. No manufacturer application details are provided for specific targets or reactions.
Research applications (general, non-target-specific)
Primary uses: biochemical screening (enzyme inhibition/activation assays), receptor/ion channel ligand characterization, phenotypic cell assays, and biophysical binding measurements (SPR, ITC, MST) once solubility is established.
Early SAR: If analog series are available in your collection, apply parallel assays to map potency shifts and physicochemical dependencies (e.g., solubility/aggregation behavior).
Orthogonal confirmation: Use LC–MS to verify compound integrity post-assay. Apply counterscreens (e.g., detergent presence, redox controls) to rule out PAINS-like behavior when applicable to the scaffold retrieved from databases.
Practical considerations
Stock preparation: Prepare fresh DMSO stocks, aliquot to avoid freeze–thaw, and protect from moisture. Measure concentration by weight-in and confirm by UV/LC–MS where possible.
Assay interference mitigation: Include solvent-only controls, test multiple final DMSO levels, and apply inner-filter effect corrections for fluorescence assays if the compound is chromophoric.
Note: No reaction chemistry or named-reaction utility is asserted for this item due to absent structural information.
Reaction Conditions
Not typically applicable to this catalog item. UCCF-339 is supplied as a research ligand rather than as a reagent for chemical transformations.
If using as a substrate or for derivatization (general guidance only)
Establish solvent system based on confirmed functional groups (e.g., polar aprotic solvents for cross-couplings; protic or mixed systems for condensations).
Determine temperature limits by DSC/TGA once the solid-state properties are known; avoid overheating unknowns.
Use standard catalytic systems (Pd for cross-coupling, HATU/EDC for amide formation) only after validating functional group compatibility.
No literature yields, temperature windows, or catalyst loadings are provided or implied for this specific item.
Safety and Handling
Item-specific safety data
GHS classification: Not specified for this item; refer to SDS.
Signal word / H-statements / pictograms: Not specified for this item; refer to SDS.
General precautions for small-molecule research ligands (not item-specific)
PPE: Wear lab coat, safety glasses, and appropriate chemically resistant gloves (e.g., nitrile). Handle powders/particulates in a fume hood to minimize inhalation exposure.
Avoid ingestion, inhalation, and skin/eye contact. Wash thoroughly after handling. Prevent environmental release.
Storage incompatibilities: Until functional groups are confirmed, segregate from strong oxidizers and bases/acids. Keep container tightly closed, desiccated, and away from direct light.
First-aid overview (consult SDS for definitive guidance)
Inhalation: Move to fresh air, monitor respiration; seek medical attention if symptoms persist.
Skin/eye contact: Rinse with copious water for at least 15 minutes; remove contaminated clothing; seek medical advice if irritation develops.
Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; seek medical attention.
Special risks
Unknown peroxide-forming or sensitizing propensity. If storing long-term, inspect solutions periodically for discoloration/precipitation and avoid evaporating to dryness unless composition is verified safe.
Always consult the product-specific SDS prior to scale-up or assay automation.
Solvent Selection
Applicability: As a Moligand-grade small molecule of unspecified structure, solvent choice should prioritize assay compatibility and compound stability.
General guidance (not item-specific specs)
Primary stock solvent: DMSO (anhydrous, assay-grade) at 10–50 mM. Filter-sterilize if required by sterile workflows.
Aqueous dilution: Typical final DMSO in assays is 0.1–1.0% v/v; confirm tolerance of your biological system to DMSO.
Alternative solvents for challenging solubility: ethanol, isopropanol, or PEG-400/H2O blends (maintain final solvent below assay interference thresholds). For biophysical assays, consider buffer with 0.01–0.05% nonionic surfactant to mitigate aggregation.
Small comparison (general)
DMSO: Excellent solvency, high polarity; broadly compatible, low volatility. May affect some enzyme/ion channel readouts above 1–2%.
Ethanol: Lower solvency for highly lipophilic scaffolds; higher volatility; commonly tolerated to ~0.5–1% in cells.
PEG-400: Good solvency, low volatility; viscosity can complicate liquid handling; can alter binding thermodynamics.
Practical tips
Perform a mini solubility screen (DMSO, ethanol, DMF, 1:1 DMSO:water) at target concentrations. Inspect for precipitation after 1:10–1:100 dilution into assay buffer.
Avoid adsorptive losses by using low-bind plastics or silanized glassware for highly lipophilic compounds.
Storage and Reconstitution
Item-specific conditions
Storage temperature: Room temperature (as provided).
Shipped in: Not specified for this item; refer to CoA/Spec Sheet.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
General best practices (not item-specific specifications)
Protect from moisture and direct light. Store in original, tightly closed container with desiccant. If hygroscopic or photosensitive behavior is suspected from the structure (once confirmed), adjust handling accordingly.
For stock solution preparation: Dissolve in anhydrous DMSO to 10–50 mM. Aliquot into amber vials or plates to minimize freeze–thaw and photodegradation.
Freeze–thaw: Avoid repeated cycles. If frozen stocks are required, store at −20 to −80°C in aliquots and thaw at room temperature before use. Record the number of thaws per aliquot.
Stability: Solution stability, water content limits, and degradation pathways are Not specified for this item; refer to CoA/Spec Sheet and verify empirically by LC–MS over the expected assay timeframe.
Research Use Note: For research use only.
Structure and Identity
Overview: UCCF-339 is listed as a small-molecule screening ligand (Moligand grade). Item-specific structural identifiers are minimal in the supplied data; consult the CoA/SDS for definitive structure.
Item-specific (from Product Data)
CAS: 652138-15-3
PubChem CID: 71376521
InChIKey: 450398 (as provided; note that typical InChIKeys are 27-character hashes — verify against CoA/PubChem)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
Structural features
Not specified in the Product Data. Without a SMILES/InChI or structure depiction, functional group and ring-system descriptions cannot be asserted. Please reference the CoA or trusted databases (e.g., PubChem CID 71376521) for the definitive 2D/3D structure and stereochemistry.
Practical identity guidance
Cross-reference the provided CAS and CID to retrieve canonical SMILES, InChI, and exact mass prior to method development or registration in ELNs.
If multiple stereochemical isomers exist in literature for this registry, confirm isomeric purity on the CoA before use in binding studies.
Synthetic Utility
Scope: Not a primary use-case. UCCF-339 is offered as a Moligand-grade screening compound, not a building block or reagent.
General guidance if synthetic derivatization is contemplated (not item-specific)
Confirm the exact structure, functional groups, and stereochemistry from CoA/CID before planning transformations.
Common derivatization pathways for small-molecule ligands (depending on scaffold) may include amide coupling, Suzuki/Miyaura cross-coupling, reductive amination, or heteroatom alkylation/acylation. Applicability is entirely structure-dependent.
For SAR, maintain a consistent core while varying substituents to probe electronic and steric effects; use parallel synthesis and rapid LC–MS analytics.
Caveat
Without structural data, no specific named-reaction suitability, protecting-group strategy, or reactivity guidance can be responsibly provided for this item.
Target Specificity
Item-specific data
Target/epitope, species selectivity, and binding mode: Not specified for this item in the Product Data.
Guidance for researchers
If UCCF-339 is used as a probe, establish target specificity via concentration–response profiling, selectivity panels, and counterscreens (e.g., orthogonal readouts, inactive analogs).
Employ kinetic analyses (kon/koff by SPR or BLI) and competition assays against reference ligands when applicable.
No claims of specificity are made for this product listing.
Domande frequenti
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 652138-15-3. InChIKey YYRINQRAIIGEQV-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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