UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED
In Vitro
UNC6852 mediates PRC2 degradation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells. UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment. UNC6852 selectively degrades EED and EZH2. UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: DLBCL Cells Concentration: 3 μM Incubation Time: 0 -10 days Result: Exhibited anti-proliferative effects. Western Blot AnalysisCell Line: HeLa Cells Concentration: 10 μM Incubation Time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours Result: Resulted in a decrease in the levels of both EED and EZH2.
Form:Solid
IC50& Target:IC50: 247 nM (EED)
Specifiche
Specifiche e purezza
≥99%
Meccanismi biochimici e fisiologici
UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED.
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
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Purezza
≥99%
Nomi e identificatori
Peso molecolare
832.97
Dati avanzati
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Solubilità
DMSO : 100 mg/mL (120.05 mM; Need ultrasonic)
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Recensioni
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Domande frequenti
What is the purity of this product?
This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2688842-08-0, the molecular formula is C43H48N10O6S, and the molecular weight is 832.97 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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