Vecuronium Bromide - 10mM in DMSO , CAS No.50700-72-6

CAS: 50700-72-6 Cat. No.: V408906 Formula: C₃₄H₅₇N₂O₄.Br Peso molecolare: 637.73 Beilstein Registry Number: 4837308 Numero EC: 256-723-9 PubChem CID: 39764

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
In vitro

Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 mM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.

In vivo

Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats.
Cell Data

cell lines：A549, H157, H460, H446, HCT116, HT29, SW480, DLD1, Caco2, LNCap, DU145, MDA468, MDA231, HEK293, and PC3-MM2

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]

WGK Germania

3

RTECS

TN4875000

PubChem CID

39764

Peso molecolare

637.73

Beilstein

4837308

Reaxy-Rn

4106207

Proprietà chimiche e fisiche

• Rotazione specifica [α]: 32° (C=1,0.05mol/L HCl)
• Punto di fusione (°C): 235 °C(dec.)