Vinpocetine - Moligand™, 10 mM in DMSO , CAS No.42971-09-5

CAS: 42971-09-5 Cat. No.: V1496217 Formula: C₂₂H₂₆N₂O₂ Peso molecolare: 350.45 Numero EC: 256-028-0 PubChem CID: 443955

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na + channels. The IC 50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB -dependent inflammatory responses by directly targeting IκB kinase complex ( IKK ) , and has been widely used for the treatment of cerebrovascular disorders.

Specifications

Specifiche e purezza

Moligand™, 10 mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Nomi e identificatori

• Isomeri SMILES: CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC
• WGK Germania: 3
• RTECS: JW4792000
• PubChem CID: 443955
• Peso molecolare: 350.45
• Reaxy-Rn: 900803

Proprietà chimiche e fisiche

• Rotazione specifica [α]: 118° (C=2,Pyridine)
• Punto di fusione (°C): 151 °C

Riferimenti

1. Chong Zhang, Zuoyan Zhang, Yueyi Wu, Yuchen Wu, Jing Cheng, Kaizhi Luo, Zhidi Li, Manman Zhang, Jian Wang, Xuesen Zhang, Yangling Li.  (2025)  Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.  eLife,      [PMID:40704992] [10.7554/eLife.98903]

2. Zhang Zuo-yan, Dong Shu-min, Liu Ye-han, Zhang Man-man, Zhang Jian-kang, Zhu Hua-jian, Shao Jia-an, Liu Hua-qing, Li Yang-ling, Zhang Chong, Zeng Ling-hui.  (2021)  Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells.  ANTI-CANCER DRUGS,  32  (7): (727).  [PMID:33735117] [10.1097/CAD.0000000000001056]

3. Shengzheng Guo, Yuechao Cao, Yuxin Zhang, Yan Wang, Zhenguo Gao, Junbo Gong.  (2024)  A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c00018]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 42971-09-5, the molecular formula is C22H26N2O2, and the molecular weight is 350.45 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.