VU 0364439 - 10mM in DMSO , CAS No.1246086-78-1

CAS: 1246086-78-1 Cat. No.: V408515 Formula: C₁₈H₁₃Cl₂N₃O₃S Peso molecolare: 422.29 PubChem CID: 46934289

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

VU 0364439 is amGlu4positive allosteric modulator (PAM), withEC50of 19.8 nM.
In vitro

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Cell Data

cell lines：HeLa, HCT116, HT29, LOVO, DU145, and NHDF cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl

PubChem CID

46934289

Peso molecolare

422.29

Obiettivi associati (umani)

GRM4 Tchem Metabotropic glutamate receptor 4 (4 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.69 mM); Ethanol: 58 mg/mL (199.69 mM); Water: Insoluble