VU 6008667 - 10mM in DMSO , CAS No.2092923-21-0

CAS: 2092923-21-0 Cat. No.: V655058 Molecular Weight: 438.85 PubChem CID: 134824563

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC 50 s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration

In Vivo

VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t 1/2 =2.3 hr) driven by a smaller volume (V ss =7.4 L/kg) and higher clearance (CL p =82 mL/min/kg), with moderate oral bioavailability (17% F) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RAT (PK study) Dosage: 1 mg/kg; 3 mg/kg Administration: oral adminstration Result: Had a desired short half-life in rat (t 1/2 = 2.3 hr), with moderate oral bioavailability (17% F).

IC50& Target:IC50: 1.2 μM (Human M5),1.6 μM (Rat M5)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC 50 s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.

Storage

Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=C(C=CC(=C1)[C@@]23C4=CC=CC=C4C(=O)N2CCN3C(=O)C5=CC(=C(C=C5)F)F)Cl
• PubChem CID: 134824563
• Molecular Weight: 438.85