VU6012962 - 10mM in DMSO , CAS No.2313526-86-0

CAS: 2313526-86-0 Cat. No.: V656429 Formula: C₂₁H₁₉F₃N₄O₄ Peso molecolare: 448.40

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM

In Vitro

VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6J male mice (8 weeks old) Dosage: 1, 3, and 10 mg/kg Administration: I.p. injections; 60 minutes prior to testing Result: Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.

IC50& Target:mGlu7 347 nM (IC 50 )

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
• Peso molecolare: 448.40