VY-3-135 - ≥98% , CAS No.1824637-41-3

CAS: 1824637-41-3 Cat. No.: V650872 Formula: C₂₆H₂₇N₃O₃ Peso molecolare: 429.51

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC 50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer.

In Vitro

VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2 low A7C11 and ACSS2 high Brpkp110 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2 high ) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2 low ) growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC 50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

CCN(C(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)=N3)C4=C3C=CC(C(NC[C@@H](C)O)=O)=C4

Peso molecolare

429.51

Proprietà chimiche e fisiche

• Solubilità: DMSO : 50 mg/mL (116.41 mM; Need ultrasonic)