W1131 , CAS No.2740522-79-4

CAS: 2740522-79-4 Cat. No.: W647770 Formula: C₂₃H₁₉N₅O₄ Peso molecolare: 429.43

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU . W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway.

In Vitro

W1131 (0-2 μM; 72 h) inhibits cell survival, migration, and invasion in gastric cancer AGS cell, and also inhibits colony formation for 3 days treatment. W1131 (0.1-3 μM; 24 h) potently inhibits the phosphorylation of STAT3 in AGS cells. W1131 (1 μM; 48 h) triggers ferroptosis and suppresses GPX4, SLC7A11, and FTH1 expression in gastric cancer. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: AGS cells Concentration: 0.1 μM, 0.3 μM, 1 μM, and 3 μM Incubation Time: 24 hours Result: Dose-dependently decreased the phosphorylated Y705-STAT3, but not STAT5, JAK2, and AKT. ImmunofluorescenceCell Line: AGS cells Concentration: 0.3 μM, 1 μM Incubation Time: 12 hours Result: Significantly promoted lipid ROS formation, and induced Fe 2+ accumulation.

In Vivo

W1131 (3 mg/kg, 10 mg/kg; i.p.; once daily for 2 weeks) inhibits tumor growth dose-dependently, and induces ferroptosis in MGC803 subcutaneous xenograft model in BALB/c-nu/nu mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MGC803 subcutaneous xenografts in mouse Dosage: 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection; once daily for 2 weeks Result: Inhibited GPX4, SLC7A11, and FTH1 expression level, indicating the induction of ferroptosis. Caused insignificant change of body weight.

Specifications

Meccanismi biochimici e fisiologici

W1131 is a potent STAT3 inhibitor, triggering ferroptosis . W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Sorrisi canonici: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(C3=CN=C4C=C(C5=CCNCC5)C=CN43)C=C2
• Peso molecolare: 429.43

Domande frequenti

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2740522-79-4, the molecular formula is C23H19N5O4, and the molecular weight is 429.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.