≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
YKL-05-099 YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.
Targets
SIK1 (Cell-free assay); SIK3 (Cell-free assay); SIK2 (Cell-free assay) 10 nM; 30 nM; 40 nM
In vitro
YKL-05-099 displays cell-based activities consistent with SIK inhibition. Pre-treatment with the indicated concentrations of YKL-05-099 for 24 hr potentiates IL-10 production by Zymosan A-stimulated BMDCs.
In vivo
Well-tolerated doses of YKL-05-099 achieve free serum concentrations above its IC50 for SIK2 inhibition for > 16 hours and reduce phosphorylation of a known SIK substrate in vivo. While in vivo active doses of YKL-05-099 recapitulate the effects of SIK inhibition on inflammatory cytokine responses, they do not induce metabolic abnormalities observed in Sik2 knockout mice. These results identify YKL-05-099 as a useful probe to investigate SIK function and further support the development of SIK inhibitors for treatment of inflammatory disorders.
Cell Research(from reference)
Cell lines：bone marrow-derived dendritic cells (BMDCs)
Concentrations：1 μM
Incubation Time：24 hr
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Piperidines |
| Subclass | Phenylpiperidines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpiperidines |
| Alternative Parents | Methoxyanilines Phenoxy compounds Methoxybenzenes Anisoles Toluenes Pyrimidones Chlorobenzenes Aralkylamines Aminopyrimidines and derivatives Alkyl aryl ethers Pyridines and derivatives Imidolactams Aryl chlorides Heteroaromatic compounds Ureas Trialkylamines Secondary amines Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylpiperidine - Methoxyaniline - Phenoxy compound - Methoxybenzene - Aniline or substituted anilines - Phenol ether - Anisole - Aralkylamine - Toluene - Pyrimidone - Halobenzene - Chlorobenzene - Aminopyrimidine - Alkyl aryl ether - Imidolactam - Benzenoid - Pyrimidine - Pyridine - Monocyclic benzene moiety - Aryl halide - Aryl chloride - Heteroaromatic compound - Urea - Tertiary aliphatic amine - Tertiary amine - Carbonic acid derivative - Azacycle - Secondary amine - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Amine - Aromatic heteropolycyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 D23061027 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061028 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061033 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061034 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061035 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061036 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061037 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061038 | Certificate of Analysis | Jan 21, 2026 | Y414441 |
| D23061032 | Certificate of Analysis | Feb 08, 2023 | Y414441 |
| Solubilità | Solubility (25°C) In vitro DMSO: 100 mg/mL (166.63 mM); Ethanol: 100 mg/mL (166.63 mM); Water: Insoluble; |
|---|---|
| DMSO (mg/mL) Solubilità massima | 100 |
| DMSO (mM) Solubilità massima | 166.636116711936 |
| Acqua (mg/mL) Solubilità massima | ＜1 |
| Peso molecolare | 600.100 g/mol |
| XLogP3 | 5.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 7 |
| Exact Mass | 599.241 Da |
| Monoisotopic Mass | 599.241 Da |
| Topological Polar Surface Area | 96.000 Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 925.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
