Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Calcolatori di soluzioni
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
Recensioni
Recensioni dei clienti
Application Protocols
No validated, item-specific protocols are provided. The following are general guidelines for small-molecule screening samples; adapt to your assay type.
General small-molecule handling
Stock solution: Prepare at 10–50 mM in an appropriate solvent (commonly anhydrous DMSO). Record exact concentration and solvent lot.
Filtration: If compatible, sterile-filter through 0.2 µm PTFE for cell-based assays to remove particulates.
Storage of stocks: Aliquot into light-protective, low-bind tubes to minimize freeze-thaw; store at 2–8 °C per Product Data when in solution only if stability is demonstrated, otherwise store as dry solid.
Assay setup
Vehicle controls: Match final solvent composition across all wells/samples.
Dose-response: Use half-log or log dilutions over a range informed by solubility and assay sensitivity (e.g., 0.03–100 µM).
Interference controls: Include counterscreens for fluorescence/absorbance interference and detergent (e.g., 0.01% Triton X-100) to probe aggregation artifacts.
Always consult the SDS/CoA and validate conditions for your specific system.
Biological Roles
Biological functions, targets, and pathways for ZY-1 are not provided in the Product Data.
Established biological role: Not specified for this item; refer to CoA/Spec Sheet or primary literature if available from your program.
General considerations for small-molecule library members
Use unbiased screening to assess potential interactions with enzymes, receptors, ion channels, or protein–protein interactions.
Apply orthogonal readouts to distinguish true target engagement from assay interference (fluorescence quenching, aggregation, redox cycling, metal chelation).
Evaluate basic ADME-related properties in vitro (stability in buffer/media, microsomal stability, plasma protein binding) only if your research scope includes such profiling. No clinical or therapeutic claims are made or implied.
All biological roles, if any, must be established experimentally by the end user.
Buffer Applications
This product is not a buffering reagent, and no acid/base properties are provided.
Buffer use: Not typically applicable. No pKa or buffer capacity data are available for this item.
Practical guidance for assay preparation (general)
If used in biochemical/cell-based assays, prepare concentrated stocks (often in DMSO), then dilute into pre-selected assay buffers (e.g., PBS, HEPES, Tris) ensuring the final organic solvent percentage is within assay tolerance.
Pre-filter assay buffers (0.2 µm) and include vehicle-matched controls to account for any solvent effects.
For any item-specific buffer compatibility or precipitation behavior, consult the CoA or perform a small pilot test.
Green Alternatives
Without structural and use-context details, specific alternatives cannot be prescribed for ZY-1. However, greener practices can be embedded in screening, handling, and any preparative work involving this compound.
Stock preparation: Use minimal DMSO concentration consistent with solubility; standardize final assay vehicle (≤0.1–1% DMSO) to reduce solvent burdens.
Miniaturization: Implement low-volume plates (1536/384-well) to reduce solvent and waste per data point.
Energy and stability: Store at 2–8 °C rather than −20/−80 °C when stability allows (as specified here), avoiding unnecessary energy use.
Illustrative comparison (general)
DCM vs EtOAc: EtOAc offers lower toxicity and environmental impact for extractions and prep TLC; consider where compatible.
THF vs 2-MeTHF: 2-MeTHF has a better safety/green profile and lower peroxide risk; verify solubility and assay interference.
All substitutions must be validated experimentally for performance and compatibility with your assays and analytics.
Pharmaceutical Uses
No pharmacopeial status or formulation role is provided. ZY-1 is supplied for research use only.
Regulatory/compendial recognition: Not specified for this item; refer to CoA/Spec Sheet.
Typical roles (not item-specific): In discovery research, small molecules may be formulated into DMSO stocks for in vitro screening or into simple vehicles (e.g., PEG/water, Captisol, or Tween-containing systems) for preclinical method development only, subject to institutional oversight. No medical or clinical use is intended or permitted.
Any development-related formulation exploration should be supported by stability and compatibility studies and institutional approvals.
Physical Properties
Item-specific physicochemical data are not provided in the Product Data. Do not assume values for method-critical work.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Melting/boiling point: Not specified for this item; refer to CoA/Spec Sheet.
Density/refractive index: Not specified for this item; refer to CoA/Spec Sheet.
pKa/logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
Solubility: Not specified for this item; refer to CoA/Spec Sheet.
Practical guidance (general, literature-style)
If structure is available, estimate lipophilicity (cLogP) and ionization (pKa) using cheminformatics (e.g., ACD/Labs, ChemAxon) to guide solvent selection.
Perform a tiered solubility screen at small scale: DMSO (anhydrous), DMF/NMP, methanol/ethanol, acetonitrile, water (with/without 0.1% base or acid), PBS. Start at 10 mM.
For solids, verify dryness (constant mass) before preparing gravimetric stocks; for oils, prepare volumetric stocks.
Record temperature and time-to-dissolve. Gentle warming (≤40 °C) and sonication can assist, avoiding prolonged heat/light exposure per storage guidance.
All item-specific properties must be confirmed against the product CoA/Spec Sheet or by user characterization (DSC/TGA, NMR, MS, Karl Fischer, HPLC).
Quality and Grades
Grade/purity and analytical release criteria are not provided in the Product Data.
Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.
Stabilizers/additives: Not specified for this item; refer to CoA/Spec Sheet.
Interpreting common grades (general guidance)
Screening/Library grade: Typically suitable for HTS/chemical biology; may prioritize identity and purity (e.g., ≥90–95% by HPLC) with limited trace-metal/UV specs.
Research/Analytical grades (e.g., HPLC, LC–MS grade solvents): Emphasize low background and UV transparency; not implied here unless stated on CoA.
Recommended quality checks
Identity: 1H/13C NMR, HRMS/LC–MS, and, if chiral, chiral HPLC or polarimetry.
Purity: HPLC/UPLC with orthogonal detection (UV/ELSD/MS). Report method, gradient, and reference standard.
Residual solvents/water: GC headspace and Karl Fischer, respectively, if performance is moisture-sensitive.
Contact Aladdin Scientific for the lot-specific CoA to confirm purity, test methods, and any stabilizers. Use the CoA as the controlling specification for regulated or method-critical work.
Reaction and Applications
The Product Data categorize ZY-1 as part of a small-molecule/compound library; no specific reactivity or functional class is provided. As such, it is more likely intended for discovery and screening workflows rather than as a general-purpose reagent.
Discovery applications (general)
Primary/secondary screening: Evaluate as a test article in biochemical, biophysical, or cell-based assays. Define concentration ranges from solubility and cytotoxicity pilot tests.
Hit validation: Confirm identity/purity by orthogonal analytics and reproduce activity across assay formats to rule out artifacts (aggregation, redox cycling, fluorescence interference).
Mechanism studies: If activity is observed, apply counterscreens (e.g., PAINS filters, detergent sensitivity, redox assays) and biophysical binding methods (SPR, DSF, MST) as appropriate.
Track compound stability by LC–MS over assay-relevant timeframes and light exposure, consistent with the storage guidance (2–8 °C, protected from light, desiccated).
No item-specific reactions, catalysts, or named transformations can be recommended without structural information.
Reaction Conditions
No structural or reactivity data are provided; therefore, no item-specific reaction conditions can be recommended.
General method-development pointers (when structure is available)
Solvent: Choose based on substrate polarity and stability (e.g., EtOAc, toluene, MeCN, 2-MeTHF, IPA, or mixed aqueous media for bioconjugation).
Temperature: Start at ambient and optimize cautiously, monitoring for decomposition by TLC/LC–MS.
Catalysts/bases/acids: Select per functional group chemistry; screen mild options first to preserve unknown labile sites.
Workup: Favor greener quench/extraction approaches; validate product stability to pH and light.
All conditions must be developed empirically once the structure and target transformation are defined.
Safety and Handling
Hazard classification is not provided in the Product Data. Handle as a potentially hazardous laboratory chemical.
GHS signal word/classification/pictograms: Not specified for this item; refer to SDS.
H-statements: Not specified for this item; refer to SDS.
General precautions (defer to SDS as authoritative)
Engineering controls: Work in a chemical fume hood; avoid aerosolization and inhalation of dust or vapors.
PPE: Lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). Use splash protection for solution prep.
Storage incompatibilities: Unknown; as a precaution, segregate from strong oxidizers/acids/bases until compatibility is known.
Light/moisture sensitivity: Store protected from light and desiccated (per Product Data), indicating potential photolability and/or hygroscopicity.
First aid (overview): Eye/skin contact—rinse with water for ≥15 min. Inhalation—move to fresh air. Ingestion—rinse mouth; seek medical attention. Bring SDS to healthcare providers.
Spill response: Contain with inert absorbent, avoid runoff, collect in a sealed container for disposal as hazardous waste.
Waste: Dispose in accordance with institutional and local regulations; do not discharge to drains.
Always consult the batch-specific SDS and CoA for definitive hazard and handling instructions.
Solvent Selection
Item-specific solubility and polarity are not disclosed. Choose solvents empirically based on small-scale screens and, when available, computed properties from the structure.
General selection workflow
Start with high-solvency polar aprotics: DMSO, DMF, NMP for concentrated stocks (e.g., 10–50 mM).
Evaluate assay-compatible diluents: aqueous buffers (PBS, HEPES), with co-solvents (≤1–2% DMSO, ≤10% MeOH/EtOH/ACN) as assay tolerates.
For nonpolar candidates, test chlorinated (DCM), ethereal (THF/2-MeTHF), and hydrocarbons (toluene, heptane) for synthetic or analytical prep, not for bioassays.
Adjust pH to enhance solubility of ionizable compounds (weak bases dissolve in acidic media; acids in basic media) within assay tolerances.
Comparison notes (general)
DMSO vs DMF: DMSO preferred for bioassays due to lower volatility and broader acceptance; DMF can plasticize labware and is less favored biologically.
ACN vs MeOH/EtOH: ACN offers low viscosity and UV cut-off; alcohols can disrupt membranes and proteins—limit % in cell assays.
Document solvent choices with final vehicle composition, ensuring matched vehicles for controls.
Storage and Reconstitution
Item-specific storage conditions are provided; reconstitution details are not.
Storage (as supplied): Store at 2–8 °C, protected from light, desiccated (per Product Data).
Shipping: Shipped on wet ice (per Product Data).
Stability: Not specified for this item; refer to CoA/Spec Sheet.
Reconstitution (general guidance)
Solvent choice: Start with anhydrous DMSO for small-molecule stocks unless contraindicated; consider MeOH/EtOH/ACN or buffered aqueous solutions as compatible.
Concentration: Common screening stocks are 10–50 mM; adjust based on solubility and assay needs.
Technique: Bring vial to room temperature in the dark before opening to avoid condensation. Weigh quickly if hygroscopic. Add solvent gradually with gentle vortexing/sonication. Filter if needed (0.2 µm PTFE for organic; PES/RC for aqueous).
Aliquoting: Dispense into amber, low-bind vials; minimize headspace. Avoid repeated freeze–thaw; use single-use aliquots.
Handling notes
Protect from ambient light during preparation and storage (foil wrap/amberware).
Maintain desiccation (desiccant packs, dry box) for the solid.
For lot-specific shelf life and re-test periods, consult the CoA/Spec Sheet.
Structure and Identity
A small-molecule screening component listed as ZY-1. Item-specific structural identifiers have not been disclosed in the Product Data.
SKU: Z1439642
Product Name: ZY-1
CAS: Z1439642 (catalog identifier provided; not a standard CAS format)
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
Structural features
Functional groups, ring systems, stereochemistry: Not specified for this item; refer to CoA/Spec Sheet.
2D structure description: Not specified for this item; refer to CoA/Spec Sheet.
Notes
This product is categorized under small molecules/compound libraries, suggesting use in screening or chemical biology workflows rather than as a bulk reagent. Provide the CoA/structure file (SDF/MOL) from your order documentation for detailed identity confirmation.
Synthetic Utility
The synthetic behavior of ZY-1 cannot be described without structural information.
Functional groups/reactivity: Not specified for this item; refer to CoA/Spec Sheet.
General guidance if derivatization is intended
Obtain full structure and impurity profile. Map potential liabilities (e.g., hydrolysis-prone esters, oxidizable anilines, photosensitive motifs).
Plan orthogonal routes for SAR: isosteric replacements, vector modifications, and solubilizing handles guided by computed pKa/logP.
Apply robust analytics (LC–MS, NMR, purity by HPLC) at each step; confirm regio-/stereochemistry as needed (2D NMR, X-ray crystallography for key intermediates).
No item-specific named reactions or conditions can be recommended at this time.
Target Specificity
Target, epitope, clone, isotype, and species reactivity fields are applicable to biologics/antibodies, not typical small molecules. For ZY-1, no target information is provided in the Product Data.
Target/biological specificity: Not specified for this item; refer to CoA/Spec Sheet or internal screening data.
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
