Amitriptyline Hydrochloride - ≥98% , Norepinephrine transporter inhibitor, CAS No.549-18-8, Norepinephrine transporter inhibitor

CAS: 549-18-8 Cat. No.: A129730 Formule: C₂₀H₂₃N · HCl Poids moléculaire: 313.86 Numéro CE: 208-964-6

QUALITÉ & PURETÉ ≥98%

Synonyms

5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride|AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH]|Amyline|Novoprotect|Tryptizol retard|AMITRIPTYLINE HYDROCHLORIDE (EP IMPURITY)|Larozyl|Tripta|Saroten Retard|Teperin|ETRAFON-A COMPONENT AMITRIPTYLINE HYDROCHLORIDE|Sarotex|AMITRIPTYLINE HYDROCHLORIDE [USP-RS]|Tridep|AMITRIPTYLINE HYDROCHLORIDE [EP IMPURITY]|Mitaptyline|Saroten|Trynol|LIMBITROL COMPONENT AMITRIPTYLINE HYDROCHLORIDE|5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride|5-(3-(Dimethylamino)propylidene) dibenzosuberane HCl|Amitriptyline hydrochloride [USP:JAN]|Amitriptyline-13C3Hydrochloride|Annolytin|Apo-Amitriptyline|Levate|Nornaln|Lentizol|Maxivalet|Tryptacap hydrochloride|Amitriptyline hydrochloride|Pinsanu|Ami-Anelun|Amitryptiline hydrochloride|Amyzol|Etrafon|Limbitrol DS|sk-Amitriptyline chloride|Amitriptyline (hydrochloride)|Novotriptyn|Proheptadien monohydrochloride|Syneudon|Triavil|Yamanouchi|1-propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride|Annoyltin|Elatrol|Trepiline|Endep|Pinsaun|AMITRIPTYLINE HYDROCHLORIDE [EP MONOGRAPH]|Domical|1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride|Amitriptyline HCl|Enafon|Kyliran|Trytomer|AMITRIPTYLINE HCL (D6)|Amitril|AMITRIPTYLINE HYDROCHLORIDE (MART.)|AMITRIPTYLINE HYDROCHLORIDE [MART.]|Amiprin|5-(3-Dimethylaminopropylidene)dibenzo(a,d)(1,4)cycloheptadiene hydrochloride|Elatrolet|Amavil|Amilit|Amineurin|Daprimen|Elavil hydrochloride|LIMBITROL DS COMPONENT AMITRIPTYLINE HYDROCHLORIDE|Miketorin|Tryptine|Oasil-M|Tryptizol|Amiplin|AMITRIPTYLINE HYDROCHLORIDE (USP MONOGRAPH)|AMITRIPTYLINE HYDROCHLORIDE (USP-RS)|3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride|3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride|AMITRIPTYLINE HYDROCHLORIDE [USP IMPURITY]|Rantoron|Amitid|AMITRIPTYLINE HYDROCHLORIDE (USP IMPURITY)|Amitriptyline hydrochloride (USP:JAN)|Sarotena|Vanatrip|ADT-Zimaia|Belpax|AMITRIPTYLINE HYDROCHLORIDE (EP MONOGRAPH)|Amitryptyline hydrochloride|Anapsique|Damilen hydrochloride

Storage

A conserver à 2-8°C, à l'abri de la lumière

Shipped In

Glace humide

Vue d’ensemble

L'amitriptyline inhibe les récepteurs de la sérotonine, de la norépinéphrine, les récepteurs 5-HT4, 5-HT2 et sigma 1 avec des IC50 de 3,45 nM, 13,3 nM, 7,31 nM, 235 nM et 287 nM, respectivement.
Le chlorhydrate d'amitriptyline est un antidépresseur tricyclique. Le chlorhydrate d'amitriptyline inhibe les transporteurs de la norépinéphrine et de la sérotonine, mais présente une forte affinité pour les récepteurs α1-adrénergiques, sérotoninergiques et muscariniques de l'acétylcholine.

Spécifications

Synonymes

5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride | AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH] | Amyline | Novoprotect | Tryptizol retard | AMITRIPTYLINE HYDROCHLORIDE (EP IMPURITY) | Larozyl | Tripta | Saroten Retard | Teperin | ETRAFON-A COMPONENT AMITRIPTYLINE HYDROCHLORIDE | Sarotex | AM Afficher plus

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Antidépresseur tricyclique ; inhibe les transporteurs de la norépinéphrine et de la sérotonine avec des Kis de 100 nM et 14,7 nM, respectivement ; forte affinité in vitro pour les récepteurs α1-adrénergiques, la sérotonine et les récepteurs muscariniques

Conditions de stockage de stockage

A conserver à 2-8°C, à l'abri de la lumière

Expédié en

Glace humide

Type d'action

INHIBITOR

Mécanisme d'action

Norepinephrine transporter inhibitor

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%

Noms et identifiants

Pubchem Sid

488181249

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488181249

Sourires canoniques

CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

IUPAC Name

N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride

InChIKey

KFYRPLNVJVHZGT-UHFFFAOYSA-N

INCHI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

Isomères SMILES

CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

WGK Allemagne

3

RTECS

HO9450000

CAS alternatif

50-48-6

Poids moléculaire

313.86

Reaxy-Rn

4164595

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4164595&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Dibenzocycloheptenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Dibenzocycloheptenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Dibenzocycloheptenes
• Alternative Parents: Trialkylamines Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Dibenzocycloheptene - Tertiary aliphatic amine - Tertiary amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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RXRA Tclin Retinoid X receptor alpha (3637 Activities)

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TRPV1 Tclin Vanilloid receptor (8273 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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ATM Tchem Serine-protein kinase ATM (4198 Activities)

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HEK293 (82097 Activities)

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HepG2 (196354 Activities)

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Lymphoblastoid cell (5959 Activities)

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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Cibles associées (non humaines)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mus musculus (284745 Activities)

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lef Anthrax lethal factor (7585 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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nfo Endonuclease 4 (425 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in Chloroform
• Sensibilité: Light sensitive；Moisture sensitive
• Point de fusion (°C): 195 °C
• Poids moléculaire: 313.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 313.16 Da
• Monoisotopic Mass: 313.16 Da
• Topological Polar Surface Area: 3.200 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 331.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3