Protéine kinase associée à la mort cellulaire

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  1. 3MB-PP1
    CAS: 956025-83-5 Formule: C17H21N5 Poids moléculaire: 295.38
    ● En stock — États-Unis Article #: M274828
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    Nom IUPAC
    1-tert-butyl-3-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
    SMILES
    CC1=CC(=CC=C1)CC2=NN(C3=NC=NC(=C23)N)C(C)(C)C
    InChIKey
    FYCOTGCSHZKHPR-UHFFFAOYSA-N
    InChI
    1S/C17H21N5/c1-11-6-5-7-12(8-11)9-13-14-15(18)19-10-20-16(14)22(21-13)17(2,3)4/h5-8,10H,9H2,1-4H3,(H2,18,19,20)
    Synonymes
    1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]- | DTXSID20647754 | GTPL7188 | 1...
  2. HS 38
    CAS: 1030203-81-6 Numéro CE: 808-443-9 Formule: C14H12CIN5O2S Poids moléculaire: 349.8
    ● En stock — États-Unis Article #: H287038
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    Nom IUPAC
    2-[[1-(3-chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide
    SMILES
    CC(C(=O)N)SC1=NC2=C(C=NN2C3=CC(=CC=C3)Cl)C(=O)N1
    InChIKey
    NASYEGAVCTZSDO-UHFFFAOYSA-N
    InChI
    1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7H,1H3,(H2,16,21)(H,18,19,22)
    Synonymes
    Z247384094 | 2-[[1-(3-chlorophenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]propanamide | 1030203-81-6 | AKOS...
  3. WAY-380496
    CAS: 304000-05-3 PubChem CID: 2138706 Formule: C17H14N2O4 Poids moléculaire: 310.30406
    10mM in DMSO
    ● En stock — États-Unis Article #: W423146
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    Nom IUPAC
    (4E)-2-(3,4-dimethoxyphenyl)-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
    SMILES
    COC1=C(C=C(C=C1)C2=NC(=CC3=CN=CC=C3)C(=O)O2)OC
    InChIKey
    VQKPPWJEZADXST-MDWZMJQESA-N
    InChI
    1S/C17H14N2O4/c1-21-14-6-5-12(9-15(14)22-2)16-19-13(17(20)23-16)8-11-4-3-7-18-10-11/h3-10H,1-2H3/b13-8+
  4. 2-(3,4-Dimethoxyphenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
    CAS: 304000-05-3 PubChem CID: 2138706 Formule: C17H14N2O4 Poids moléculaire: 310.30406
    ● En stock — États-Unis Article #: W418489
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    Nom IUPAC
    (4E)-2-(3,4-dimethoxyphenyl)-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
    SMILES
    COC1=C(C=C(C=C1)C2=NC(=CC3=CN=CC=C3)C(=O)O2)OC
    InChIKey
    VQKPPWJEZADXST-MDWZMJQESA-N
    InChI
    1S/C17H14N2O4/c1-21-14-6-5-12(9-15(14)22-2)16-19-13(17(20)23-16)8-11-4-3-7-18-10-11/h3-10H,1-2H3/b13-8+
  5. DRAK2-IN-1
    CAS: 871837-60-4 PubChem CID: 136175114 Formule: C21H20N4O3 Poids moléculaire: 376.41
    ◐ .Sur commande · 8–12 semaines Article #: D650626
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    Nom IUPAC
    N-[2-hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]pentanamide
    SMILES
    CCCCC(=O)NC1=CC2=C(C=C1)NC(=C2C3=C(C4=CC=CC=C4N3)N=O)O
    InChIKey
    ZFZLSKZDOULLMO-UHFFFAOYSA-N
    InChI
    1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23-24,27H,2-3,8H2,1H3,(H,22,26)
  6. TC-DAPK 6
    CAS: 315694-89-4 PubChem CID: 5676111 Formule: C17H12N2O2 Poids moléculaire: 276.29
    ◐ .Sur commande · 8–12 semaines Article #: T646454
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    Nom IUPAC
    (4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
    SMILES
    C1=CC=C(C=C1)C=CC2=NC(=CC3=CN=CC=C3)C(=O)O2
    InChIKey
    GFGMISOSPOPSHN-QCTDOKRBSA-N
    InChI
    1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+
    Synonymes
    EX-A2167 | Z56820688 | EN300-260619 | AC-35960 | EN300-7536106 | 2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4,...
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Foire aux questions

How is the DAPK listing put together?
It draws on reported DAPK annotations within Apoptosis and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a DAPK modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the DAPK entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for DAPK compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For DAPK work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the DAPK compound I need is not listed?
Search by CAS number or SMILES first, since analogs of DAPK compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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