Mps1

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  1. N8-[(2S)-3,3-dimethylbutan-2-yl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine, Inhibitor of TTK protein kinase
    CAS: 1578244-34-4 Formula: C24H29N7O Molecular Weight: 431.5334
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ◐ .Made to order · 8–12 wks Item #: N174563
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    IUPAC Name
    8-N-[(2S)-3,3-dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CC(C(C)(C)C)NC1=NC=CC2=CN=C(N=C21)NC3=C(C=C(C=C3)C4=CN(N=C4)C)OC
    InChIKey
    XTJZKALDRPVFSN-HNNXBMFYSA-N
    InChI
    1S/C24H29N7O/c1-15(24(2,3)4)28-22-21-17(9-10-25-22)12-26-23(30-21)29-19-8-7-16(11-20(19)32-6)18-13-27-31(5)14-18/h7-15H,1-6H3,(H,25,28)(H,26,29,30)/t1show more
  2. Mps1-IN-1 dihydrochloride
    CAS: 1883548-93-3 PubChem CID: 91691119 Formula: C28H33N5O4S.2HCl Molecular Weight: 608.58
    ◐ .Made to order · 8–12 wks Item #: M287223
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    IUPAC Name
    1-[3-methoxy-4-[[4-(2-propan-2-ylsulfonylanilino)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]piperidin-4-ol;dihydrochloride
    SMILES
    CC(C)S(=O)(=O)C1=CC=CC=C1NC2=CC(=NC3=C2C=CN3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC.Cl.Cl
    InChIKey
    HFJLUXGXTPNYTQ-UHFFFAOYSA-N
    InChI
    1S/C28H33N5O4S.2ClH/c1-18(2)38(35,36)26-7-5-4-6-23(26)30-24-17-27(32-28-21(24)10-13-29-28)31-22-9-8-19(16-25(22)37-3)33-14-11-20(34)12-15-33;;/h4-10,1show more
    Synonyms
    1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidin...
  3. AZ 3146, Inhibitor of TTK protein kinase
    CAS: 1124329-14-1 Formula: C24H32N6O3 Molecular Weight: 452.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: A127268
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    IUPAC Name
    9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
    SMILES
    CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
    InChIKey
    YUKWVHPTFRQHMF-UHFFFAOYSA-N
    InChI
    1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,show more
    Synonyms
    AKOS024457919 | SW219317-1 | HY-14710 | CCG-264989 | AZ3146 | AZ-3146 | 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperid...
  4. TC Mps1 12
    CAS: 1206170-62-8 PubChem CID: 70682875 Formula: C17H20N6O Molecular Weight: 324.38
    ● In Stock — US Item #: T287052
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    IUPAC Name
    4-[[4-amino-6-(tert-butylamino)-5-cyanopyridin-2-yl]amino]benzamide
    SMILES
    CC(C)(C)NC1=C(C(=CC(=N1)NC2=CC=C(C=C2)C(=O)N)N)C#N
    InChIKey
    XDEFNAWAKYQBQY-UHFFFAOYSA-N
    InChI
    1S/C17H20N6O/c1-17(2,3)23-16-12(9-18)13(19)8-14(22-16)21-11-6-4-10(5-7-11)15(20)24/h4-8H,1-3H3,(H2,20,24)(H4,19,21,22,23)
    Synonyms
    4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
  5. BAY 1217389, Dual specificity protein kinase TTK inhibitor
    CAS: 1554458-53-5 Formula: C27H24F5N5O3 Molecular Weight: 561.50
    10mM in DMSO
    ● In Stock — US Item #: B421851
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    IUPAC Name
    N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(3,3,3-trifluoropropylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
    SMILES
    CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
    InChIKey
    WNEILUNVMHVMPH-UHFFFAOYSA-N
    InChI
    1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,show more
    Synonyms
    AKOS032944938 | AC-36064 | HY-12859 | NSC787026 | NSC-787026 | BAY1217389 | BAY-1217389 | GTPL12705 | M964LB1114 | EX...
  6. BAY 1217389, Dual specificity protein kinase TTK inhibitor
    CAS: 1554458-53-5 Formula: C27H24F5N5O3 Molecular Weight: 561.50
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US Item #: B413947
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    Technical Identifiers
    IUPAC Name
    N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-(3,3,3-trifluoropropylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide
    SMILES
    CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
    InChIKey
    WNEILUNVMHVMPH-UHFFFAOYSA-N
    InChI
    1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,show more
    Synonyms
    AKOS032944938 | AC-36064 | HY-12859 | NSC787026 | NSC-787026 | BAY1217389 | BAY-1217389 | GTPL12705 | M964LB1114 | EX...
  7. BOS172722
    CAS: 1578245-44-9 Formula: C24H30N8O Molecular Weight: 446.55
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: B421892
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    IUPAC Name
    8-N-(2,2-dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CCOC1=C(C=CC(=C1)C2=NN=CN2C)NC3=NC=C4C=C(N=C(C4=N3)NCC(C)(C)C)C
    InChIKey
    SGWLRDAOCLITOM-UHFFFAOYSA-N
    InChI
    1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(Hshow more
    Synonyms
    compound 36 [PMID: 30199249] | s8911 | 1578245-44-9 | N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl...
  8. BOS172722
    CAS: 1578245-44-9 Formula: C24H30N8O Molecular Weight: 446.55
    ● In Stock — US Item #: B414264
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    IUPAC Name
    8-N-(2,2-dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine
    SMILES
    CCOC1=C(C=CC(=C1)C2=NN=CN2C)NC3=NC=C4C=C(N=C(C4=N3)NCC(C)(C)C)C
    InChIKey
    SGWLRDAOCLITOM-UHFFFAOYSA-N
    InChI
    1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(Hshow more
    Synonyms
    compound 36 [PMID: 30199249] | s8911 | 1578245-44-9 | N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl...
  9. Empesertib (BAY1161909), Dual specificity protein kinase TTK inhibitor
    CAS: 1443763-60-7 Formula: C29H26FN5O4S Molecular Weight: 559.61
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: E413946
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    IUPAC Name
    (2R)-2-(4-fluorophenyl)-N-[4-[2-(2-methoxy-4-methylsulfonylanilino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide
    SMILES
    CC(C1=CC=C(C=C1)F)C(=O)NC2=CC=C(C=C2)C3=CN4C(=NC(=N4)NC5=C(C=C(C=C5)S(=O)(=O)C)OC)C=C3
    InChIKey
    NRJKIOCCERLIDG-GOSISDBHSA-N
    InChI
    1S/C29H26FN5O4S/c1-18(19-4-9-22(30)10-5-19)28(36)31-23-11-6-20(7-12-23)21-8-15-27-33-29(34-35(27)17-21)32-25-14-13-24(40(3,37)38)16-26(25)39-2/h4-18H,show more
    Synonyms
    A908652 | (-)-BAY-1161909 | Benzeneacetamide, 4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]tria...
  10. MPI-0479605, Inhibitor of TTK protein kinase
    CAS: 1246529-32-7 Formula: C22H29N7O Molecular Weight: 407.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: M413761
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    IUPAC Name
    6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
    SMILES
    CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4
    InChIKey
    OVJBNYKNHXJGSA-UHFFFAOYSA-N
    InChI
    1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,show more
    Synonyms
    N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
  11. MPI-0479605, Inhibitor of TTK protein kinase
    CAS: 1246529-32-7 Formula: C22H29N7O Molecular Weight: 407.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US Item #: M421046
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    Technical Identifiers
    IUPAC Name
    6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
    SMILES
    CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4
    InChIKey
    OVJBNYKNHXJGSA-UHFFFAOYSA-N
    InChI
    1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,show more
    Synonyms
    N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
  12. MPS1-IN-1, Inhibitor of TTK protein kinase
    CAS: 1125593-20-5 Formula: C28H33N5O4S Molecular Weight: 535.66
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: M612011
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    IUPAC Name
    1-[3-methoxy-4-[[4-(2-propan-2-ylsulfonylanilino)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]piperidin-4-ol
    SMILES
    CC(C)S(=O)(=O)C1=CC=CC=C1NC2=CC(=NC3=C2C=CN3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC
    InChIKey
    NMJMRSQTDLRCRQ-UHFFFAOYSA-N
    InChI
    1S/C28H33N5O4S/c1-18(2)38(35,36)26-7-5-4-6-23(26)30-24-17-27(32-28-21(24)10-13-29-28)31-22-9-8-19(16-25(22)37-3)33-14-11-20(34)12-15-33/h4-10,13,16-18show more
    Synonyms
    AVB59320 | SCHEMBL4051419 | BCP27688 | MLS003230944 | Mps1-IN-1 | NCGC00387463-04 | SMR001913509 | 1-(4-((4-((2-(isop...
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Frequently Asked Questions

What can I find under Mps1?
This listing collects compounds associated with Mps1 within our Cytoskeleton area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Mps1?
Consider the reported potency of each Mps1 compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Mps1 compounds?
Each Mps1 product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Mps1 compounds by activity or structure?
Yes. Filter the Mps1 listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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