MAPKAPK2 (MK2)

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  1. RMM 46
    CAS: 1307896-46-3 PubChem CID: 67206797 Formule: C24H26N4O5 Poids moléculaire: 450.5
    ◐ .Sur commande · 8–12 semaines Article #: R288282
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    Nom IUPAC
    (E)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enamide
    SMILES
    CC(C)(CO)NC(=O)C(=CC1=CC2=C(C=C1)NN=C2C3=CC(=C(C(=C3)OC)OC)OC)C#N
    InChIKey
    FCCMYBKAZCDQGX-LZYBPNLTSA-N
    InChI
    1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,show more
    Synonymes
    2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
  2. TC-S 7006, Inhibitor of mitogen-activated protein kinase kinase kinase 8
    CAS: 871307-18-5 Numéro CE: 111-094-9 PubChem CID: 9549300 Formule: C21H14ClFN6 Poids moléculaire: 404.83
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .Sur commande · 8–12 semaines Article #: T287927
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    Nom IUPAC
    4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
    SMILES
    C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl
    InChIKey
    NMEUKWOOQOHUNA-UHFFFAOYSA-N
    InChI
    1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
    Synonymes
    DTXSID20946032 | 4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile | 4-(3...
  3. MK2-IN-3, Inhibitor of MAPK activated protein kinase 2;Inhibitor of MAPK activated protein kinase 3;Inhibitor of MAPK activated protein kinase 5
    CAS: 724711-21-1 Formule: C21H16N4O Poids moléculaire: 340.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — États-Unis Article #: M333061
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    Nom IUPAC
    2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
    SMILES
    C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4
    InChIKey
    OWFLADWRSCINST-UHFFFAOYSA-N
    InChI
    1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26)
    Synonymes
    1,5,6,7-Tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one | MK2 Inhibitor III
  4. Quazinone (Ro 13-6438)
    CAS: 70018-51-8 PubChem CID: 135418296 Formule: C11H10ClN3 Poids moléculaire: 235.67
    ◐ .Sur commande · 8–12 semaines Article #: Q336048
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    Nom IUPAC
    (3R)-6-chloro-3-methyl-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one
    SMILES
    CC1C(=O)NC2=NC3=C(CN12)C(=CC=C3)Cl
    InChIKey
    BHZFZYLBVSWUMT-ZCFIWIBFSA-N
    InChI
    1S/C11H10ClN3O/c1-6-10(16)14-11-13-9-4-2-3-8(12)7(9)5-15(6)11/h2-4,6H,5H2,1H3,(H,13,14,16)/t6-/m1/s1
    Synonymes
    Quazinona | Ro 13-6438; Ro 13-6438/006 | (3R)-6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one | QUAZ...
  5. CMPD-1, Inhibitor of MAPK activated protein kinase 2
    CAS: 41179-33-3 Formule: C22H20FNO2 Poids moléculaire: 349.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
    ● En stock — États-Unis Article #: C286549
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    Nom IUPAC
    4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide
    SMILES
    C1=CC=C(C(=C1)C2=CC=C(C=C2)CCCC(=O)NC3=CC=C(C=C3)O)F
    InChIKey
    ODYAQBDIXCVKAE-UHFFFAOYSA-N
    InChI
    1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
    Synonymes
    4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide | EX-A7609 | AKOS024456977 | GTPL6009 | MAPKAPK2a Inhibito...
  6. MK-2 Inhibitor III
    CAS: 1186648-22-5 PubChem CID: 25163932 Formule: C21H16N4O・H2O Poids moléculaire: 358.39
    ◐ .Sur commande · 8–12 semaines Article #: M334622
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    Nom IUPAC
    2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrate
    SMILES
    C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O
    InChIKey
    NIKCVKMHGQQSRN-UHFFFAOYSA-N
    InChI
    1S/C21H16N4O.H2O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15;/h1-5,7,9-12,25H,6,8H2,(H,23,26);1H2
    Synonymes
    2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
  7. MK2 Inhibitor III, Inhibitor of MAPK activated protein kinase 2;Inhibitor of MAPK activated protein kinase 3;Inhibitor of MAPK activated protein kinase 5
    CAS: 724711-21-1 Formule: C21H16N4O Poids moléculaire: 340.38
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● En stock — États-Unis Article #: M425672
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    Nom IUPAC
    2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
    SMILES
    C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4
    InChIKey
    OWFLADWRSCINST-UHFFFAOYSA-N
    InChI
    1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26)
    Synonymes
    1,5,6,7-Tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one
  8. PF 3644022, Inhibitor of MAPK activated protein kinase 2
    CAS: 1276121-88-0 PubChem CID: 44631903 Formule: C21H18N4OS Poids moléculaire: 374.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● En stock — États-Unis Article #: P288030
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    Nom IUPAC
    (15R)-15-methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one
    SMILES
    CC1CNC2=C(C(=O)N1)SC3=C2C4=C(C=C3)N=C(C=C4)C5=CN=C(C=C5)C
    InChIKey
    CMWRPDHVGMHLSZ-GFCCVEGCSA-N
    InChI
    1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1
    Synonymes
    (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-on...
  9. Zunsemetinib
    CAS: 1640282-42-3 Formule: C25H22ClF2N5O3 Poids moléculaire: 513.92
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — États-Unis Article #: Z614989
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    Nom IUPAC
    3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-one
    SMILES
    Cc1cc(OCc2ncc(F)cc2F)c(Cl)c(=O)n1c1cc(ncc1C)c1nc(ncc1)C(C)(C)O
    InChIKey
    FQPQMJULRZINPV-UHFFFAOYSA-N
    InChI
    1S/C25H22ClF2N5O3/c1-13-10-30-18(17-5-6-29-24(32-17)25(3,4)35)9-20(13)33-14(2)7-21(22(26)23(33)34)36-12-19-16(28)8-15(27)11-31-19/h5-11,35H,12H2,1-4H3
    Synonymes
    (1(2H),4'-Bipyridin)-2-one, 3-chloro-4-((3,5-difluoro-2-pyridinyl)methoxy)-2'-(2-(1-hydroxy-1-methylethyl)-4-pyrimidi...
  10. MK2-IN-1 hydrochloride
    CAS: 1314118-94-9 PubChem CID: 70681199 Formule: C27H26Cl2N4O2 Poids moléculaire: 509.4
    ◐ .Sur commande · 8–12 semaines Article #: M651058
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    Nom IUPAC
    5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide;hydrochloride
    SMILES
    C1CN(CCN1)C2=CC=C(C=C2)N(CC3=CC=CC=N3)C(=O)C4=CC=C(O4)C5=CC=C(C=C5)Cl.Cl
    InChIKey
    AZDOSXSDARWKGX-UHFFFAOYSA-N
    InChI
    1S/C27H25ClN4O2.ClH/c28-21-6-4-20(5-7-21)25-12-13-26(34-25)27(33)32(19-22-3-1-2-14-30-22)24-10-8-23(9-11-24)31-17-15-29-16-18-31;/h1-14,29H,15-19H2;1H
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Foire aux questions

Which compounds are listed for MAPKAPK2 (MK2)?
Compounds associated with MAPKAPK2 (MK2) are grouped here under the MAPK/ERK Pathway classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does MAPKAPK2 (MK2) sit within MAPK/ERK Pathway?
MAPKAPK2 (MK2) is one target listing within the MAPK/ERK Pathway classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from MAPKAPK2 (MK2)?
For compounds listed under MAPKAPK2 (MK2), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for MAPKAPK2 (MK2)?
Browse the parent MAPK/ERK Pathway listing to reach targets neighbouring MAPKAPK2 (MK2), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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