Allopurinol - Moligand™, 10mM in DMSO , Xanthine dehydrogenase inhibitor, CAS No.315-30-0, Xanthine dehydrogenase inhibitor

CAS: 315-30-0 Cat. No.: A409140 分子式: C₅H₄N₄O 分子量: 136.11 Beilstein Registry Number: 26(3/4)4298 EC番号: 206-250-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase , used to treat gout or kidney stones, and to decrease levels of uric acid.
In vitro

Allopurinol reverses the increased xanthine oxidase activity in ischemia-reperfusion injury of neonatal rat hearts. Allopurinol (10 mM) treatment suppresses xanthine oxidase activity induced by hypoxia-reoxygenation injury and the production of reactive oxygen species. Allopurinol also decreases the concentration of intracellular Ca2+ increased by enhanced xanthine oxidase activity.

In vivo

Allopurinol shows abnormal pyrimidine metabolism together with renal toxicity which could be ameliorated by uridine, indicating that Allopurinol essentially causes pyrimidine metabolism abnormality leading to renal impairment in normal mice. Allopurinol increases urinary OD excretion to an extent similar to that in normal mice administered the same dose of Allopurinol in DNFB-sensitized mice. Allopurinol promotes a clinical improvement which is accompanied by a reduction in the parasitic load in the blood, skin and lymph nodes but, even after long period of allopurinol administration alone, Leishmania may persist in dog tissues in Leishmania-infected dogs. Allopurinol prevents early alcohol-induced liver injury in rats, most likely by preventing oxidant-dependent activation of NF-kappaB. Allopurinol protects dose-dependently against acetaminophen-induced cell injury, the loss of ATP and the increase of the GSSG content in the total liver and in the mitochondrial compartment without inhibiting reactive metabolite formation in mice. Allopurinol almost completely inhibits hepatic xanthine oxidase and dehydrogenase activity, but only high doses prevents the increase of the mitochondrial GSSG content.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Xanthine dehydrogenase inhibitor

名前と識別子

異性体SMILES

C1=NNC2=C1C(=O)NC=N2

WGKドイツ

2

RTECS

UR0785000

UN番号

2811

包装グループ

I

分子量

136.11

Beilstein

26(3/4)4298

Reaxy-Rn

133199

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=133199&ln=

関連ターゲット（人間）

XDH Tclin Xanthine dehydrogenase/oxidase (11 Activities)

Discover Target: XDH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: 384°C

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 315-30-0, the molecular formula is C5H4N4O, and the molecular weight is 136.11 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.