10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
DMOG DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase , leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy .
In vitro
DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.
In vivo
DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
Cell Data
cell lines：
Concentrations：~100 μM
Incubation Time：72-96 hours
Powder Purity:≥97%
| Isomeric SMILES | COC(=O)CNC(=O)C(=O)OC |
|---|---|
| WGK Germany | 3 |
| Molecular Weight | 175.14 |
| Reaxy-Rn | 2096268 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2096268&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Boil Point(°C) | 182 °C/12 mmHg |
|---|---|
| Melt Point(°C) | 51 °C |
| 1. Chen Li, Zhiwei Liu, Song Liu, Santosh K. Tiwari, Kunyapat Thummavichai, Oluwafunmilola Ola, Zhiyuan Ma, Shenghua Zhang, Nannan Wang, Yanqiu Zhu. (2022) Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin. APPLIED SURFACE SCIENCE, [PMID:] [10.1016/j.apsusc.2022.153132] |
| 2. Xiao Xu, Xiaohu Ge, Hongbo Ci, Maitiseyiti Abulaihaiti, JianPing Yang, YangYang Li, Feng Zhu. (2025) PAI-1 promotes thromboangiitis obliterans progression through NF-κB-NLRP3 pathway activation via HIF-1α-dependent signaling. MICROVASCULAR RESEARCH, [PMID:41238034] [10.1016/j.mvr.2025.104885] |
| 3. Heng-Qing Huan, Yu-Bing Ding, Zi-Ang Qian, Jie Ji, Xian-Hui Ning, Shao-Wu Yin, Kai Zhang. (2025) Interleukin-22 functions to alleviate hypoxia-induced intestinal inflammation by modulating pro- and anti-inflammatory factors in Pelteobagrus fulvidraco. ZOOLOGICAL RESEARCH, 46 (5): (1137). [PMID:41017399] [10.24272/j.issn.2095-8137.2024.477] |
