3,3,3-Tris(4-chlorophenyl)propionic Acid: FAQs & Properties

3,3,3-Tris(4-chlorophenyl)propionic acid is a halogenated triaryl carboxylic acid used as a specialty building block and reference compound in organic synthesis and pharmaceutical research.

Chemical Name

3,3,3-Tris(4-chlorophenyl)propionic acid

SKU

T102998

Molecular Formula

C21H15Cl3O2

Functional Groups

Carboxylic acid (-COOH); three para-chlorophenyl substituents

Compound Class

Halogenated triarylacetic acid derivative

Primary Use

Organic synthesis building block; pharmaceutical intermediate

What Is 3,3,3-Tris(4-chlorophenyl)propionic Acid?

3,3,3-Tris(4-chlorophenyl)propionic acid (SKU T102998) is an organic compound featuring a propionic acid backbone substituted at the beta-carbon with three para-chlorophenyl groups. Its molecular formula is C₂₁H₁₅Cl₃O₂, and it belongs to the class of halogenated triaryl carboxylic acids. The presence of three electron-withdrawing para-chloro substituents significantly influences the compound's electronic properties, acidity, and reactivity compared with unsubstituted triarylpropionic acid analogues.

This compound is catalogued by Aladdin Scientific under product code T102998 and is intended for use in research laboratory settings by qualified scientists.

Physicochemical Properties and Solubility

3,3,3-Tris(4-chlorophenyl)propionic acid is expected to be a solid at room temperature, consistent with other high-molecular-weight triaryl carboxylic acids. The three para-chlorophenyl groups confer pronounced lipophilicity, which has direct implications for solubility:

• Aqueous solubility: Expected to be very low due to the highly hydrophobic triaryl core. Direct dissolution in water is not recommended without co-solvents.
• Organic solvent solubility: The compound is anticipated to be soluble in polar aprotic solvents such as DMSO and DMF, and in common organic solvents such as dichloromethane, ethyl acetate, and tetrahydrofuran. Solubility in ethanol and methanol may be moderate.
• pH-dependent behavior: As a carboxylic acid, solubility in aqueous media increases under alkaline conditions where the carboxylate anion is formed.

Note: Exact solubility values are not specified in the current product documentation. Researchers should determine solubility empirically for their specific experimental conditions.

Storage, Handling, and Safety Considerations

Storage: In the absence of specific stability data in the product documentation, general best practices for halogenated aromatic carboxylic acids apply. Store in a tightly sealed container in a cool, dry, well-ventilated area away from light, moisture, and incompatible materials such as strong bases and oxidising agents. Refrigeration (2–8 °C) may prolong shelf life.

Handling: Use appropriate personal protective equipment (PPE) including laboratory coat, chemical-resistant gloves, and eye protection. Work in a fume hood when handling powders or solutions to avoid inhalation of dust or vapour.

Safety: The compound contains three organochlorine moieties. Although it is not classified as a pesticide or pharmaceutical in this context, researchers should consult the Safety Data Sheet (SDS) supplied by Aladdin Scientific before use. Dispose of waste in accordance with local regulations governing halogenated organic waste.

Review flag: Specific GHS hazard classifications and precautionary statements should be confirmed from the official SDS for T102998.

Research Applications and Synthetic Utility

3,3,3-Tris(4-chlorophenyl)propionic acid is primarily of interest as a synthetic building block and reference standard. Key areas of utility include:

• Pharmaceutical intermediate: The triarylmethyl (trityl) motif is a recognised pharmacophore scaffold. Chlorine substitution modulates lipophilicity and binding affinity, making such compounds relevant in medicinal chemistry exploration.
• Organic synthesis: The carboxylic acid functionality can be engaged in esterification, amide coupling, reduction, or decarboxylation reactions, providing access to a range of tris(4-chlorophenyl)methyl-containing derivatives.
• Reference and analytical standard: High-purity samples serve as reference compounds for method development and validation in analytical chemistry.
• Structure–activity relationship (SAR) studies: As part of a series of triarylpropionic acid analogues, this compound can inform SAR investigations exploring the effect of halogen substituents on biological or physicochemical endpoints.

Note: Specific published biological activity data for this exact compound were not identified in the source material. Researchers should conduct independent literature searches.

Ordering and Product Availability at Aladdin Scientific

3,3,3-Tris(4-chlorophenyl)propionic acid is available from Aladdin Scientific under SKU T102998. To place an order or request pricing and availability information:

• Search for SKU T102998 on the Aladdin Scientific website.
• Contact your regional Aladdin Scientific sales representative or customer service team for bulk quantities, custom pack sizes, or certificate of analysis (CoA) requests.
• Provide your institutional purchase order details during checkout to expedite processing.

Aladdin Scientific offers a range of pack sizes to accommodate both small-scale exploratory research and larger preparative needs. Please confirm current stock availability and lead times with the sales team, as these may vary.

Frequently asked questions

What is the molecular formula and molecular weight of 3,3,3-Tris(4-chlorophenyl)propionic acid?

The molecular formula of 3,3,3-Tris(4-chlorophenyl)propionic acid is C21H15Cl3O2. The molecular weight can be calculated from this formula as approximately 422.7 g/mol, though researchers should confirm the exact value from the product's Certificate of Analysis (CoA) available from Aladdin Scientific.

In which solvents can 3,3,3-Tris(4-chlorophenyl)propionic acid be dissolved for laboratory use?

Due to its highly lipophilic triaryl structure, this compound is expected to dissolve well in polar aprotic solvents such as DMSO and DMF, as well as in organic solvents including dichloromethane, ethyl acetate, and THF. Aqueous solubility is anticipated to be very low; alkaline aqueous solutions may dissolve the carboxylate form. Researchers are advised to verify solubility experimentally under their specific conditions.

How should 3,3,3-Tris(4-chlorophenyl)propionic acid be stored to maintain its integrity?

Store the compound in a tightly sealed container in a cool, dry, and well-ventilated location, protected from light and moisture. Refrigeration at 2–8 °C is generally recommended for long-term storage of sensitive organic compounds. Always consult the Safety Data Sheet (SDS) and Certificate of Analysis provided by Aladdin Scientific for compound-specific storage guidance.

What are the typical research applications of 3,3,3-Tris(4-chlorophenyl)propionic acid?

This compound serves primarily as an organic synthesis building block for constructing tris(4-chlorophenyl)methyl-containing derivatives via esterification, amide coupling, or reduction reactions. It may also function as a reference standard in analytical chemistry and as a tool compound in medicinal chemistry structure–activity relationship studies involving halogenated triaryl scaffolds.

Where can I purchase 3,3,3-Tris(4-chlorophenyl)propionic acid and what SKU should I use?

3,3,3-Tris(4-chlorophenyl)propionic acid is available from Aladdin Scientific under SKU T102998. You can order directly through the Aladdin Scientific website by searching for T102998, or by contacting the customer service team for pricing, availability, and bulk order inquiries.

References

1. Aladdin Scientific product listing: 3,3,3-Tris(4-chlorophenyl)propionic acid, SKU T102998.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. General reference for carboxylic acid reactivity and triarylmethane chemistry.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.