7-Hydroxy-2-methyl-3-phenyl-chromen-4-one: Key Facts & FAQs

7-Hydroxy-2-methyl-3-phenyl-chromen-4-one is a synthetic isoflavone-scaffold flavonoid bearing a 7-hydroxyl group, a 2-methyl substituent, and a 3-phenyl group on the chromen-4-one core, available from Aladdin Scientific (SKU H338724) for use as a research reagent in chemical biology and natural product studies.

Product Name

7-Hydroxy-2-methyl-3-phenyl-chromen-4-one

SKU / Catalog Number

H338724

Santa Cruz Reference Number

sc-278609

Compound Class

Isoflavone-type flavonoid (chromen-4-one scaffold)

Key Structural Features

7-hydroxyl group, 2-methyl group, 3-phenyl substituent on chromen-4-one core

Supplier

Aladdin Scientific

Chemical Identity and Structure

7-Hydroxy-2-methyl-3-phenyl-chromen-4-one belongs to the isoflavone-related subfamily of flavonoids, characterised by a benzopyran-4-one (chromen-4-one) core. Its distinguishing features are a free hydroxyl group at the 7-position (a common motif in bioactive flavonoids), a methyl group at the 2-position, and a phenyl ring at the 3-position. The 3-phenyl substitution pattern is the hallmark of isoflavone-type compounds, distinguishing them from flavones (where the aryl group resides at position 2). This structural arrangement influences planarity, hydrogen-bond donor/acceptor capacity, and potential interactions with biological targets.

Research Applications

Flavonoids with a 7-hydroxy chromenone scaffold are widely employed in chemical biology research as tool compounds for studying flavonoid-protein interactions, enzyme inhibition, and antioxidant mechanisms. The 7-hydroxyl group is frequently associated with activity in assays involving kinases, cytochrome P450 enzymes, and receptors relevant to inflammation pathways. As a research reagent, 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one (H338724) is suitable for structure-activity relationship (SAR) studies comparing methylated and unmethylated isoflavone analogues, as well as for use as a reference standard in analytical chemistry workflows.

Researchers should design appropriate in vitro assay controls and validate purity by HPLC before use in biological experiments.

Handling, Storage, and Solubility

As a hydroxylated flavonoid, 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one should be stored in a cool, dry, well-ventilated area away from light and moisture to prevent oxidation of the phenolic hydroxyl group. Common organic solvents used for dissolving structurally similar flavonoids include dimethyl sulfoxide (DMSO), ethanol, and methanol; aqueous solubility is expected to be limited due to the hydrophobic chromenone and phenyl moieties. Stock solutions should be aliquoted and stored at –20 °C to minimise freeze-thaw degradation. Always consult the product-specific Safety Data Sheet (SDS) provided by Aladdin Scientific before handling.

Note: Specific solubility values and confirmed storage conditions for H338724 are not provided in the current source material and should be verified from the product SDS or Certificate of Analysis (CoA).

Ordering and Product Information

7-Hydroxy-2-methyl-3-phenyl-chromen-4-one is catalogued by Aladdin Scientific under SKU H338724. This compound is also cross-referenced with Santa Cruz Biotechnology catalogue number sc-278609, which may assist researchers reconciling legacy orders or literature references. To place an order, request a quotation, or obtain a Certificate of Analysis (CoA) or Safety Data Sheet (SDS), contact Aladdin Scientific directly through the website or your regional sales representative. Bulk quantities and custom packaging may be available upon request.

Purity, Grade, and Quality Specifications

Research-grade reagents such as H338724 are intended for laboratory research use only and are not for use in diagnostic, therapeutic, or clinical procedures. Purity specifications, analytical data (e.g., NMR, HPLC purity), and batch-specific information are detailed in the Certificate of Analysis (CoA) accompanying each lot. Researchers requiring high-purity material for quantitative assays should confirm the reported purity grade against their experimental requirements prior to purchase. Aladdin Scientific recommends contacting the technical team for the most current lot-specific CoA.

Note: Specific purity percentages for H338724 are not stated in the available source material; consult the CoA for confirmed values.

Frequently asked questions

What is the catalog number for 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one at Aladdin Scientific?

The Aladdin Scientific catalog number (SKU) for 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one is H338724. It is also cross-referenced with Santa Cruz Biotechnology number sc-278609.

What class of compound is 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one, and what are its key structural features?

It belongs to the isoflavone-type subclass of flavonoids, built on a chromen-4-one (benzopyranone) scaffold. Its key structural features are a 7-hydroxyl group, a 2-methyl substituent, and a 3-phenyl group, which together define its physicochemical and potential biological properties.

In what solvents can 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one be dissolved for research use?

Based on the physicochemical characteristics of structurally analogous hydroxylated flavonoids, DMSO, ethanol, and methanol are commonly used solvents. Aqueous solubility is generally limited for compounds in this class. Researchers should verify solubility experimentally and consult the product's CoA or SDS for confirmed data specific to H338724.

How should H338724 be stored to maintain stability?

As a phenolic flavonoid, H338724 should be stored in a cool, dry, dark environment to minimise oxidative degradation of the hydroxyl group. Prepared stock solutions are generally best kept at –20 °C in sealed aliquots. Always refer to the product SDS and CoA provided by Aladdin Scientific for lot-specific storage recommendations.

Is 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one suitable for clinical or diagnostic use?

No. This compound is supplied as a research-grade reagent intended solely for in vitro laboratory research. It is not approved, validated, or intended for use in diagnostic, therapeutic, clinical, or veterinary applications.

References

1. Santa Cruz Biotechnology product reference sc-278609, cross-referenced with Aladdin Scientific SKU H338724.
2. General textbook-level knowledge on flavonoid and isoflavone chemistry, chromen-4-one scaffold properties, and flavonoid biological activity.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.