Hydroxyl Protecting Groups

In multistep organic synthesis and medicinal chemistry, the value of some intermediates does not lie in corresponding to one specific end product, but in their ability to define chain length, reaction sites, and the sequence of subsequent transformations in advance.

When selecting a hydroxyl protecting group, the first question is usually not “Which one is the most stable?” but rather at what later stage, and under what type of conditions, this protecting group is intended to be removed. In protecting-group methodology, deprotection conditions are ...