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Mitsunobu Reaction

Browse protocols, FAQs, guidelines, and technical articles tagged “Mitsunobu Reaction”, newest first. For research use only.

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Why Primary and Secondary Amines Have Difficulty Participating Directly in the Classical Mitsunobu Reaction: Mechanism, Inversion of Configuration, and Reaction Scope of BEHT-Mediated Alcohol Amination

The classical Mitsunobu reaction can activate alcohols under relatively mild conditions and form new C—N, C—O, or C—S bonds through nucleophilic substitution. With suitable chiral secondary alcohols, the reaction is generally accompanied by inversion of configuration. It is therefore ...

Updated ·26 min read

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