α-Picoline-borane, 2-Methylpyridine borane, PICB
α-Picoline-borane, 2-Methylpyridine borane, PICB
Topic
Chemical synthesis
Techniques for detecting, quantifying and localizing antigens and antibodies — ELISA, Western blotting, immunohistochemistry and flow cytometry. Below are the protocols, FAQs and technical articles in our knowledge base tagged with this topic.
73 resources · protocols, FAQs & articles
α-Picoline-borane, 2-Methylpyridine borane, PICB
α-Picoline-borane, 2-Methylpyridine borane, PICB
Strategies and Progress in the Asymmetric Catalytic Synthesis of Chiral 1,2-Bis(boronic) Esters: Route Types, Selectivity Challenges, and Sequential Site Utilization (with Product Selection Navigator and Tables 1–4)
In synthetic chemistry, a “useful building block” typically has two hallmarks: it reduces step count when constructing complex structures, and it continues to create value through downstream transformations.
Selenium
Selenium
Red-Al, Sodium bis(2-methoxyethoxy)aluminumhydride
Red-Al,Sodium bis(2-methoxyethoxy)aluminumhydride
Schwartz's Reagent, Zirconocene chloride hydride
Zirconocene chloride hydride is capable of facilitating an efficient reduction process, converting tertiary amides into aldehydes while tolerating the presence of esters. When alkynes and alkenes undergo hydrozirconation with Schwartz's reagent, zirconium-containing products are generated, ...
Rongalite, Sodium hydroxymethanesulfinate
Rongalite generates in situ sulfite anions. Hence, sodium hydroxymethanesulfinate can serve both as a reducing agent and as a reagent for sulfone synthesis.
Potassium iodide
Potassium iodide is an ionic compound which is made of the following ions: K+ I−. It crystallises in the sodium chloride structure. It is produced industrially by treating KOH with iodine.
Potassium borohydride
The targeted 1,2-reduction of enones is accomplished by employing sodium borohydride in conjunction with CeCl₃.
PMHS, Polymethylhydrosiloxane
Polymethylhydrosiloxane (PMHS), a byproduct generated within the silicone manufacturing sector, serves as an economical, user-friendly, and eco-conscious reducing agent. Notably, PMHS exhibits superior stability in the presence of air and moisture compared to alternative silanes, enabling ...
Potassium
This reductive coupling process unfolds in two sequential stages. Initially, the coupling reaction is triggered by the transfer of a single electron from an alkali metal (potassium) to the carbonyl groups.
Tris(dimethylamino)phosphine, P(NMe2)3
Tris(dimethylamino)phosphine may serve as a deoxygenation and desulfurization reagent.
Niobium
Niobium and columbium are interchangeable names for the chemical element possessing the atomic number 41. In 1801, it was named columbium, whereas in 1950, the International Union of Pure and Applied Chemistry officially designated it as niobium (Nb).
Phosphorous acid
Phosphorous acid
Pinacolborane
Pinacolborane
Spirocyclic Building Blocks for Scaffold Assembly
Currently, chemists are becoming increasingly interested in spirocyclic building block molecules containing quaternary rings. Aladdin Scientific offers a range of spiral building block products, including various types of spiral [3.3] heptanes1 and spiral [3.4] octanes2-3. These building blocks ...
α-Picoline-borane, 2-Methylpyridine borane, PICB
α-Picoline-borane, 2-Methylpyridine borane, PICB
Applications of Flavors and Fragrances in the Food Industry
Flavors and fragrances hold a pivotal role in the food industry, as they elevate the sensory attributes of food products and profoundly shape consumer preferences. While fragrances are added in minimal quantities, they significantly enhance the taste of food. They are indispensable for imparting ...
Neodymium (low valent)
Neodymium, denoted by the symbol Nd and possessing an atomic number of 60, classifies as a chemical element. As the fourth entity within the lanthanide sequence, it is categorized among the rare-earth metals. Characterized by its hardness and slight malleability, this silvery metal undergoes ...
Molybdenum hexacarbonyl
Molybdenum hexacarbonyl
Di-tert-butyl peroxide (DTBP)
Di-tert-butyl peroxide (DTBP)
Tetramethyl-1,4-benzoquinone（DQ）
Tetramethyl-1,4-benzoquinone（DQ）
3,3',5,5'-tetra-tert-butyldiphenoquinone (DPQ)
The commercially available organic oxidant 3,3',5,5'-tetra-tert-butyldiphenoquinone (DPQ) can be readily synthesized through the oxidation of the affordable o,o'-di-tert-butylphenol.
Nickel
Nickel
Lithium tri-tert-butoxyaluminum hydride, LTBA
Lithium tri-tert-butoxyaluminum hydride, LTBA
Magnesium
Magnesium
1,3-Diiodo-5,5-Dimethylhydantoin, DIH
1,3-Diiodo-5,5-dimethylhydantoin(DIH) exhibits a reactivity similar to molecular iodine but is easier to manage since it does not sublime as a solid reagent. Additionally, DIH serves as a viable substitute for NIS (N-iodosuccinimide) in the iodination of arenes or enols.
Diethyl allyl phosphate, allyl diethyl phosphate (DEAP)
Diethyl allyl phosphate, allyl diethyl phosphate (DEAP)
3-Mercaptopropionic acid, 3-MPA
3-Mercaptopropionic acid, 3-MPA
Diisopropyl azodicarboxylate (DIAD)
Diisopropyl azodicarboxylate (DIAD)
Aladdin®Halogenation Reagents
In the field of organic chemistry, halogenation reactions and their products - halogenation compounds - do play a crucial role. These reactions not only enrich the toolbox of organic synthesis, but also greatly expand the application range of halogenation compounds in complex molecular ...
Dimethyl sulfoxide (DMSO)
Dimethyl sulfoxide (DMSO)
Manganese
A highly effective nickel-catalyzed process enables the direct reductive cross-coupling of equimolar quantities of alkyl and aryl halides in the presence of manganese, demonstrating excellent yield, functional group compatibility, and operational simplicity. This transformation bypasses the ...
Dess-Martin periodinane (DMP)
Dess-Martin periodinane (DMP) is a commercially available chemical that decomposes slowly. However, it is sensitive to heat and shock, and exhibits an exothermic reaction when heated above 130 °C.
Single-Electron Oxidation-Induced Chemical Transformations: Carbon-Carbon Bond Formation and Selective Oxaziridine Rearrangement
Visible-light photoredox catalysis represents a significant and expanding research domain within the realm of eco-friendly and sustainable organic synthesis. Our group has conducted extensive research on the single-electron transfer (SET) mechanism in photoredox catalysis, aiming to develop more ...
2,5-di-tert-butyl-1,4-benzoquinone (2,5-DTBQ)
2,5-di-tert-butyl-1,4-benzoquinone (2,5-DTBQ)
1-Hydrosilatrane
1-Hydrosilatrane, depicted in Figure 1, serves as a highly versatile hydride reagent. It can be employed in various reduction reactions to synthesize alcohols, amines, their chiral derivatives, and esters from aldehydes and ketones.
Methanol
An anionic iridium complex, [Cp*Ir(2,2'-bpyO)(OH)][Na], serves as a versatile and highly effective catalyst for the transfer hydrogenation of ketones and imines using methanol as the hydrogen source under base-free conditions. The reaction demonstrates excellent tolerance to nitro, cyano, and ...
Lithium triethylborohydride, LiTEBH, Superhydride
LiBHEt3 is an exceptionally potent reducing agent, surpassing even lithium aluminum hydride in efficiency. For instance, LiTEBH facilitates rapid reduction of carbonyl compounds, esters, acid chlorides, acid anhydrides, and tertiary amides into alcohols, as well as the conversion of disulfides ...
2,3-Dichloro-5,6-Dicyanobenzoquinone, DDQ
DDQ (2,3-dichloro-5,6-dicyanobenzoquinone), which exhibits stronger oxidizing properties than 1,4-benzoquinone, serves as a reagent in oxidative coupling and cyclization reactions, as well as in the dehydrogenation of hydroaromatic compounds.
LAH, Lithium aluminum hydride, Lithium tetrahydridoaluminate
LAH, Lithium aluminum hydride, Lithium tetrahydridoaluminate
Dicumyl Peroxide (DCP)
A cascade reaction, catalyzed by copper, results in the formation of quinazolinone through a radical methylation, sp3 C-H amination, and oxidation process.
Aladdin®Grignard Reagents
Aladdin®Grignard Reagents
Diethyl azodicarboxylate (DEAD)
Diethyl azodicarboxylate (DEAD)
Lithium
The Birch Reduction provides a means to obtain substituted 1,4-cyclohexadienes.
1,3-Dibromo-5,5-Dimethylhydantoin, DBDMH
1,3-Dibromo-5,5-Dimethylhydantoin, DBDMH
Electrochemical Allylic C-H Oxidation with N-Hydroxytetrachlorophthalimide (TCNHPI)
Professor Phil Baran and his team have created a new reagent called N-Hydroxytetrachlorophthalimide (H401609), which offers a cost-effective, scalable, and safe alternative for commonly used chemical transformations such as allylic oxidations, as well as Negishi and Suzuki-Miyaura cross-coupling ...
White Catalyst
The "White catalyst", developed by Professor M. Christina White and her team at the University of Illinois-Urbana, has proven to be an outstanding catalyst for the functionalization of allylic carbon centers.
Pyridinium Chlorochromate (PCC) Corey-Suggs Reagent
Pyridinium Chlorochromate (PCC) Corey-Suggs Reagent
MCAT-53™ Catalyst for Ruthenium Formation
MCAT-53™, a novel ruthenium catalyst, simplifies C-H activated C-C coupling in water by eliminating extra steps and avoiding solvents like NMP.
Diversinates™: Any-Stage Functionalization of (Hetero)aromatic Scaffolds
The core of the chemical industry revolves around the synthesis of heteroaromatic and aromatic compounds. Given the escalating demand for novel chemical entities amidst dwindling resources and tight timelines imposed on research projects, there is a pressing need for a swift method to diversify ...
Cumene Hydroperoxide (CMHP, CHP)
Cumene hydroperoxide is a stable organic peroxide that can be found commercially with a purity of approximately 80%. When dissolved in benzene at a concentration of 0.2 M, it has a half-life of 29 hours at 145°C.
Aladdin®Oxidation Reagents
Oxidation reaction, as one of the cornerstones of organic chemistry, its core lies in promoting the release of electrons from target substances, thereby triggering profound changes in chemical properties.
Diethylsilane
Diethylsilane
Jørgensen’s Organocatalysts
Professor Karl Anker Jørgensen and his research team have synthesized (R)- and (S)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether compounds, which excel as chiral organocatalysts for the direct and asymmetric α-functionalization process of aldehydes.
Rh2(esp)2 Catalyst
The Stanford-based Du Bois group has refined the catalytic prowess of Rh in oxidative C-H activation reactions, targeting sulfamate, sulfamide, carbamate, urea, and guanidine substrates. This enhancement stems from their ingenious substitution of tetramethylated m-benzenediproprionic acid 1 ...
1,3-Dimethylimidazol-2-ylidene borane (diMe-Imd-BH3)
NHC-trihydroboranes are white solids that are stable to air, water, and even chromatography. However, 1,3-dimethylimidazol-2-ylidene borane is a surprisingly good hydride donor that is comparable to anionic reagents such as NaCNBH3. The reagent can be used for reductive amination procedures and ...
DIBAL-H, Diisobutylaluminium hydride
DIBAL-H, Diisobutylaluminium hydride
Solid-Phase Peptide Synthesis (SPPS) — Efficient Strategies and Innovative Techniques
Solid-phase peptide synthesis (SPPS) is a revolutionary biochemical technique that has become the primary method for synthesizing peptides and proteins since its introduction in the 1960s. Robert Bruce Merrifield first proposed the concept of SPPS in 1963, and this groundbreaking work not only ...
N-tert-butylbenzenesulfinimidoyl chloride
A range of unsymmetrical ketones has been prepared in good yields from aldehydes in one simple synthetic operation by addition of organolithium compounds followed by an oxidation using N-tert-butylphenylsulfinimidoyl chloride.
tert-Butyl hydroperoxide, TBHP
Various aromatic, aliphatic and conjugated alcohols were transformed into the corresponding carboxylic acids and ketones in good yields with aq 70% t-BuOOH in the presence of catalytic amounts of bismuth(III) oxide. This method possesses does not involve cumbersome work-up, exhibits ...
Tert-Butyl Nitrite (TBN)
The use of tert-butyl nitrite as the co-catalyst in a 2-azaadamantane-N-oxyl(AZADO)- and 9-azanoradamantane-N-oxyl(nor-AZADO)-catalyzed efficient aerobic oxidation of primary alcohols in MeCN instead of the previously reported AcOH provides the corresponding aldehydes selectively. The addition ...
Tert-Butyl peroxybenzoate, TBPB
The reaction of tert-butyl peroxybenzoate (TBPB) and ammonia/amines provides the corresponding primary, secondary, and tertiary amides under catalyst- and solvent-free conditions in excellent yields. TBPB is an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the ...
1,4-Cyclohexadiene, CHD
1,4-Cyclohexadiene can act as hydrogen atom donor due to aromatization as driving force.
Greener Methods: Catalytic Amide Bond Formation
The amide bond is one of the most commonly used chemical bonds in organic synthesis. The methods used to form this important functional group are often superchemically stoichiometric, leading to significant waste in the process. These factors led the American Chemical Society Green Chemistry ...
C–H Amination
The Du Bois group at Stanford University has achieved significant advancements in Rh-catalyzed C–H amination through oxidative cyclization of carbamate, sulfamate, sulfamide, urea, and guanidine substrates. This methodology produces 1,2- and 1,3-heteroatom motifs masked within 5- and ...
Hypophosphorous acid and hypophosphite salts
Hypophosphorous acid and hypophosphite salts
Diethoxymethylsilane, DEMS
Chiral rhodium-bis(oxazolinyl)phenyl complexes catalyze the conjugate hydrosilylation of 3,3-diarylacrylate derivatives to prepare optically active 3,3-diarylpropanoate derivatives in high yields and high enantioselectivities.
sec-Butanol, 2-Butanol
Butan-2-ol, or sec-butanol, is an organic compound with formula CH3CH(OH)CH2CH3. Its structural isomers are 1-butanol, isobutanol, and tert-butanol. 2-Butanol is chiral and thus can be obtained as either of two stereoisomers designated as (R)-(−)-butan-2-ol and (S)-(+)-butan-2-ol. It is ...
108 SadPhos, Find Your Own Chiral Phosphine Ligands/Catalysts
Professor Zhang Junliang's research group from Fudan University has developed 12 series of chiral tert-butylsulfinamide phosphine ligands/catalysts (Sulfinamide Phosphine, collectively referred to as SadPhos) based on the design concept of non-C2 symmetry, combining rigidity and flexibility, as ...
Recent Advances in the Catalytic Transformations to Access Alkylsulfonyl Fluorides as SuFEx Click Hubs
The quest for innovative and effective techniques to produce sulfonyl fluorides is of significant interest due to their extensive applications across various fields. Sulfur(VI) fluoride exchange (SuFEx) click chemistry has recently gained prominence as one of the leading methods in this domain. ...
N-Fluoro-2,4,6-trimethylpyridinium triflate
N-Fluoro-2,4,6-trimethylpyridinium triflate
New Synthesis Method of New Nickel Reagent and Boric Acid (Ester)
Boric acid (ester) is an important molecular synthesis block, especially special boric acid (ester) such as heterocyclic ring, allyl, saturated hydrocarbon and substrate containing two functional groups, are popular blocks in synthetic chemistry.
Related topics
Techniques often explored alongside immunological experiments.