Mitomycin C - ≥98%, from Streptomyces caespitosus , CAS No.50-07-7

Name: Mitomycin C - ≥98%, from Streptomyces caespitosus , CAS No.50-07-7
SKU: M476633
Availability: InStock

CAS: 50-07-7 Cat. No.: M476633 分子式: C₁₅H₁₈N₄O₅ 分子量: 334.33 Beilstein Registry Number: 7231816 EC番号: 200-008-6

18 Citations COA

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Mitomycin C - ≥98%, from Streptomyces caespitosus CAS No(50-07-7) M476633 by Aladdin Scientific

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注文可能

GRADE & PURITY ≥98% from Streptomyces caespitosus

Synonyms

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads,FedEx DG Service

概要 Specifications 製品の性質名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質よくある質問と記事 Citations of This Product ソリューション計算機レビュー

🧪

Why this grade

≥98%, from Streptomyces caespitosus for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads,FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Mitomycin C is a systemic chemotherapy compound and an antibiotic obtained fromStreptomyces caespitosus. It is the first bioreductive alkylating agent to be identified and is a derivative of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate.Chemical structure: AziridineMitomycin C fromStreptomyces caespitosushas been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line.

λmax；216, 359 nm

Specifications

同義語

仕様と純度

≥98%, from Streptomyces caespitosus

生化学的・生理学的メカニズム

Mitomycin C causes the cross-linking of double-stranded DNA, which results in mutagenesis, inhibition of DNA synthesis, initiation of DNA repair events, and activation of apoptosis. The capability to inhibit DNA synthesis is attributable to the aminoquino

保管条件

Protected from light,Store at -20°C

入荷

Ice chest + Ice pads,FedEx DG Service

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%

製品の性質

ALogP

-0.4

名前と識別子

パブケム・シド

504750932

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504750932

カノニカル・スマイル

CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

IUPAC Name

[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

InChIKey

NWIBSHFKIJFRCO-WUDYKRTCSA-N

INCHI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

異性体SMILES

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

WGKドイツ

代替CAS番号

1404-00-8

UN番号

2811

包装グループ

分子量

334.33

Beilstein

7231816

Reaxy-Rn

630306

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=630306&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Indoles and derivatives
    - Subclass Indolequinones
      - Level5 Mitomycins, mitosane and mitosene derivatives
        Level6 Mitomycins

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Indoles and derivatives
Subclass	Indolequinones
Intermediate Tree Nodes	Mitomycins, mitosane and mitosene derivatives
Direct Parent	Mitomycins
Alternative Parents	Indoles Quinones Pyrrolizines Piperazines Vinylogous amides Pyrrolines Pyrrolidines Azacyclic compounds Aziridines Carboximidic acids and derivatives Dialkylamines Enamines Hydrocarbon derivatives Imines Organopnictogen compounds Monoalkylamines Organic oxides
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Mitomycin - Indole - Quinone - Pyrrolizine - 1,4-diazinane - Piperazine - Pyrrolidine - Vinylogous amide - Pyrroline - Ketone - Aziridine - Carboximidic acid derivative - Secondary aliphatic amine - Enamine - Azacycle - Secondary amine - Primary aliphatic amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Imine - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Primary amine - Amine - Aliphatic heteropolycyclic compound
説明	This compound belongs to the class of organic compounds known as mitomycins. These are polycyclic compounds with a structure based on an aziridine ring linked to a 7-amino-6-methyl-cyclohexa[b]pyrrolizine-5,8-dione.
External Descriptors	Quinones
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

関連ターゲット（人間）

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

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DHFR Tclin Dihydrofolate reductase (3072 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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F2 Tclin Thrombin (11687 Activities)

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CA2 Tclin Carbonic anhydrase II (17698 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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HMGCR Tclin HMG-CoA reductase (2475 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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ACE Tclin Angiotensin-converting enzyme (1423 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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HRH2 Tclin Histamine H2 receptor (5428 Activities)

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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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CALCR Tclin Calcitonin receptor (2215 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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OPRK1 Tclin Kappa opioid receptor (16155 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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ESR2 Tclin Estrogen receptor beta (9272 Activities)

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CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

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関連ターゲット（非人間）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Abcb1b P-glycoprotein 1 (174 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Caulobacter vibrioides (128 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Salmonella typhimurium (15756 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Bacillus subtilis (32866 Activities)

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Streptomyces (126 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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B16 (5829 Activities)

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CCRF S-180 (1031 Activities)

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CHO-AA8 (574 Activities)

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CHO-K1 (1115 Activities)

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DC3F (23 Activities)

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DC3F/AD-II (6 Activities)

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EL4 (235 Activities)

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EMT6 (738 Activities)

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L1210 (27553 Activities)

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MDCK (10148 Activities)

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P388 (20296 Activities)

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P388/ADR (1216 Activities)

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P388/S (109 Activities)

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Vero (26788 Activities)

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XC (7 Activities)

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C6 (2371 Activities)

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H4 (48 Activities)

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NIH3T3 (5395 Activities)

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V79 (1637 Activities)

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B16-F10 (4610 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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Raoultella planticola (618 Activities)

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作用メカニズム

証明書（CoA、COO、BSE/TSEと分析図）

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46 results found

Lot Number	Certificate Type	日付	商品
J2610695	Certificate of Analysis	Sep 22, 2026	M476633
J2610690	Certificate of Analysis	Sep 22, 2026	M476633
J2610689	Certificate of Analysis	Sep 22, 2026	M476633
J2610679	Certificate of Analysis	Sep 22, 2026	M476633
F2608471	Certificate of Analysis	May 26, 2026	M476633
F2608467	Certificate of Analysis	May 26, 2026	M476633
F2608466	Certificate of Analysis	May 26, 2026	M476633
F2608465	Certificate of Analysis	May 26, 2026	M476633
G2528301	Certificate of Analysis	Jul 05, 2025	M476633
D2607018	Certificate of Analysis	Jul 05, 2025	M476633
G2528300	Certificate of Analysis	Jul 05, 2025	M476633
G2528303	Certificate of Analysis	Jul 05, 2025	M476633
G2528304	Certificate of Analysis	Jul 05, 2025	M476633
D2523130	Certificate of Analysis	Apr 15, 2025	M476633
D2523131	Certificate of Analysis	Apr 15, 2025	M476633
D2523133	Certificate of Analysis	Apr 15, 2025	M476633
D2523134	Certificate of Analysis	Apr 15, 2025	M476633
L2416676	Certificate of Analysis	Nov 28, 2024	M476633
L2416673	Certificate of Analysis	Nov 28, 2024	M476633
L2416674	Certificate of Analysis	Nov 28, 2024	M476633
L2416675	Certificate of Analysis	Nov 28, 2024	M476633
I2425551	Certificate of Analysis	Sep 13, 2024	M476633
I2425552	Certificate of Analysis	Sep 13, 2024	M476633
I2425553	Certificate of Analysis	Sep 13, 2024	M476633
I2425554	Certificate of Analysis	Sep 13, 2024	M476633
C2429862	Certificate of Analysis	Mar 14, 2024	M476633
C2429863	Certificate of Analysis	Mar 14, 2024	M476633
C2429864	Certificate of Analysis	Mar 14, 2024	M476633
I2410219	Certificate of Analysis	Mar 14, 2024	M476633
I2413039	Certificate of Analysis	Mar 14, 2024	M476633
J2326541	Certificate of Analysis	Sep 19, 2023	M476633
A2404381	Certificate of Analysis	Sep 19, 2023	M476633
L2320113	Certificate of Analysis	Sep 19, 2023	M476633
J2326583	Certificate of Analysis	Sep 19, 2023	M476633
J2326582	Certificate of Analysis	Sep 19, 2023	M476633
J2326581	Certificate of Analysis	Sep 19, 2023	M476633
D2318962	Certificate of Analysis	Mar 24, 2023	M476633
D2318928	Certificate of Analysis	Mar 24, 2023	M476633
D2318927	Certificate of Analysis	Mar 24, 2023	M476633
D2318920	Certificate of Analysis	Mar 24, 2023	M476633
D2318919	Certificate of Analysis	Mar 24, 2023	M476633
H2315345	Certificate of Analysis	Mar 24, 2023	M476633
H2302248	Certificate of Analysis	Mar 24, 2023	M476633
D2318934	Certificate of Analysis	Mar 24, 2023	M476633
D2318939	Certificate of Analysis	Mar 24, 2023	M476633
D2318940	Certificate of Analysis	Mar 24, 2023	M476633

化学的性質と物理的性質

溶解度	Slightly soluble in water, methanol, or ethanol, almost insoluble in ether, solubility in H2O:<0.1 mg/mL (insoluble)
感度	Light sensitive；Heat sensitive；Moisture sensitive
屈折率	1.68 (Predicted)
沸点（°C）	581.8° C at 760 mmHg (Predicted)
融点（°C）	64℃
分子量	334.330 g/mol
XLogP3	-0.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	334.128 Da
Monoisotopic Mass	334.128 Da
Topological Polar Surface Area	147.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	757.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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Mitomycin C - ≥98%, from Streptomyces caespitosus , CAS No.50-07-7

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Mitomycin C - ≥98%, from Streptomyces caespitosus , CAS No.50-07-7

Storage & shipping

Quality documents

Literature proof

概要

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

顧客レビュー

📚 Citations by Application

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