2-D08 - ≥98%(HPLC) , CAS No.144707-18-6

CAS: 144707-18-6 Cat. No.: D167318 Fórmula: C₁₅H₁₀O₅ Peso molecular: 270.24 Número CE: 808-530-1

GRADE & PURITY ≥98%(HPLC)

Synonyms

PD044048 | HY-114166 | SCHEMBL1772778 | D82631 | 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one | BCP18314 | AMY31051 | AS-16368 | 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE | 2D08;2 D08 | AKOS027322100 | 2',3',4'-trihydroxyflavone | CCG-267148 | s8696 | 2-(2,3

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinónimos

PD044048 | HY-114166 | SCHEMBL1772778 | D82631 | 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one | BCP18314 | AMY31051 | AS-16368 | 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE | 2D08;2 D08 | AKOS027322100 | 2',3',4'-trihydroxyflavone | CCG-267148 | s8696 | 2-(2,3

Especificações e pureza

≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

2-D08 is a small ubiquitin-like modification protein (sumoylation) inhibitor with cell permeability. 2-D08 also inhibited Axl with IC50 of 0.49 nM.

Condições de armazenamento de armazenamento

Store at 2-8°C

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%(HPLC)

Nomes e identificadores

Pubchem Sid

504769239

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504769239

Sorrisos canónicos

C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O

IUPAC Name

2-(2,3,4-trihydroxyphenyl)chromen-4-one

InChIKey

JJAXTFSPCLZPIW-UHFFFAOYSA-N

INCHI

1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H

SMILES isoméricas

C1=CC=C2C(=C1)C(=O)C=C(O2)C3=C(C(=C(C=C3)O)O)O

WGK Alemanha

3

Peso molecular

270.24

Reaxy-Rn

26588215

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26588215&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Flavonoids
      • Subclass Flavones

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Flavonoids
• Subclass: Flavones
• Intermediate Tree Nodes: Not available
• Direct Parent: Flavones
• Alternative Parents: 4'-hydroxyflavonoids 3'-hydroxyflavonoids Chromones 5-unsubstituted pyrrogallols Pyranones and derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Heteroaromatic compounds Polyols Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 3'-hydroxyflavonoid - 4'-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - 5-unsubstituted pyrrogallol - Benzenetriol - Pyrogallol derivative - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Organoheterocyclic compound - Oxacycle - Polyol - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: Light sensitive
• Peso molecular: 270.240 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 270.053 Da
• Monoisotopic Mass: 270.053 Da
• Topological Polar Surface Area: 87.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 418.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 144707-18-6, the molecular formula is C15H10O5, and the molecular weight is 270.24 g/mol. InChIKey JJAXTFSPCLZPIW-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.