6,7-Dimethoxycoumarin - ≥98% , CAS No.120-08-1
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SKU
D101246
Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
An agent that can up-regulate the expression and activate CAR
Mais informação
| CAS | 120-08-1 |
|---|---|
| Sinónimos | AC-11197 | Q15424761 | Maybridge4_003009 | SCHEMBL240777 | STL193280 | CCG-41207 | Dimethylaesculetin | A14856 | Benzopyran-2-one, 6,7-dimethoxy- | o-Methylscopoletin | ACon1_002079 | Scoparone | UNII-H5841PDT4Y | Benzopyran-2-one, 6,7-dimethoxy- (9CI) | |
| Especificações e pureza | ≥98% |
| Condições de armazenamento de armazenamento | Room temperature |
| Enviado em | Normal |
| Product Description | Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells. |
| Pubchem Sid | 504751672 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751672 |
| Solubilidade | Soluble in DMSO (15 mg/ml), and water (partly miscible). |
| Número de identificação | MFCD00006871 |
| Número CE | 204-369-0 |
| PubChem CID | 8417 |
| Fórmula molecular | C11H10O4 |
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