9-Phenanthrol - Moligand™, 10mM in DMSO , Channel blocker of TRPM4, CAS No.484-17-3, Channel blocker of TRPM4

CAS: 484-17-3 Cat. No.: P424202 Fórmula: C₁₄H₁₀O Peso molecular: 194.23 Número CE: 207-602-4 PubChem CID: 10229

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

HY-108457 | NSC50554 | NSC-50554 | UNII-9FYU45OV9H | DTXCID7027592 | DZKIUEHLEXLYKM-UHFFFAOYSA- | 4-06-00-04937 (Beilstein Handbook Reference) | Tox21_300618 | BRN 2047057 | GTPL4114 | SY113803 | Phenanthren-9-ol | SCHEMBL508755 | BDBM50526033 | CCRIS 184

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Sinónimos

HY-108457 | NSC50554 | NSC-50554 | UNII-9FYU45OV9H | DTXCID7027592 | DZKIUEHLEXLYKM-UHFFFAOYSA- | 4-06-00-04937 (Beilstein Handbook Reference) | Tox21_300618 | BRN 2047057 | GTPL4114 | SY113803 | Phenanthren-9-ol | SCHEMBL508755 | BDBM50526033 | CCRIS 184

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

CHANNEL BLOCKER

Mecanismo de ação

Channel blocker of TRPM4

Nomes e identificadores

• Pubchem Sid: 528762960
• Sorrisos canónicos: C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
• IUPAC Name: phenanthren-9-ol
• InChIKey: DZKIUEHLEXLYKM-UHFFFAOYSA-N
• INCHI: 1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
• SMILES isoméricas: C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
• WGK Alemanha: 3
• RTECS: SF8288000
• PubChem CID: 10229
• Peso molecular: 194.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenanthrenes and derivatives
      • Subclass Phenanthrols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenanthrenes and derivatives
• Subclass: Phenanthrols
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenanthrols
• Alternative Parents: Naphthols and derivatives 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Phenanthrol - 1-naphthol - 2-naphthol - Naphthalene - 1-hydroxy-2-unsubstituted benzenoid - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenanthrols. These are compounds containing a phenanthrene (or its hydrogenated derivative) to which a hydroxyl group is attached.
• External Descriptors: phenanthrol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 (0 Activities)

Discover Target: TRPM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HL-60 (67320 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Peso molecular: 194.230 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 194.073 Da
• Monoisotopic Mass: 194.073 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 225.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referências

1. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2023)  Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38171066] [10.1016/j.chroma.2023.464625]

2. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang.  (2023)  Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:37931428] [10.1016/j.chroma.2023.464491]

3. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang.  (2022)  High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2022.122610]

4. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang.  (2022)  Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:36099739] [10.1016/j.jhazmat.2022.129920]

5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang.  (2022)  Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations.  Environmental Science-Nano,  9  (9): (3562-3580).  [PMID:] [10.1039/D2EN00543C]

6. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong.  (2022)  Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content.  QUIMICA NOVA,  45  (2): (145-151).  [PMID:] [10.21577/0100-4042.20170808]

7. Xin-Qiao He, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2021)  Thiol–Yne Click Postsynthesis of a Sulfonate Group-Enriched Magnetic Microporous Organic Network for Efficient Extraction of Benzimidazole Fungicides.  ACS Applied Materials & Interfaces,      [PMID:34374514] [10.1021/acsami.1c11148]

8. Xin-Qiao He, Yuan-Yuan Cui, Xiao-Hui Lin, Cheng-Xiong Yang.  (2021)  Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis.  TALANTA,      [PMID:34215105] [10.1016/j.talanta.2021.122471]

9. Fan Libing, Ma Qianli, Tian Jiao, Li Dan, Xi Xue, Dong Xiangting, Yu Wensheng, Wang Jinxian, Liu Guixia.  (2019)  Conjugate Electrospinning Construction of Microyarns with Synchronous Color-Tuned Photoluminescence and Tunable Electrical Conductivity.  JOURNAL OF ELECTRONIC MATERIALS,  48  (3): (1511-1521).  [PMID:] [10.1007/s11664-018-06914-9]

10. Zhongyue Zhou, Haoran Liu, Xinghua Liu, Chih-Hao Chin.  (2025)  Oxygenated Polycyclic Aromatic Hydrocarbons as Key Coke Precursors in Coke Formation during Zeolite-Catalyzed Furfural Pyrolysis.  Applications in Energy and Combustion Science,      [PMID:] [10.1016/j.jaecs.2025.100389]

11. Jin Chen, Yiwei Fang, Borui Sun, Ying Xu, Wanyi Chen, Kai zhao, Huiping Zhang.  (2025)  Association between polycyclic aromatic hydrocarbons exposure and gestational hypertension: Insights from global and dose metabolomics analysis.  Journal of Environmental Sciences,      [PMID:41461512] [10.1016/j.jes.2025.05.030]