Acolbifene - Moligand™, 10 mM in DMSO , CAS No.182167-02-8

CAS: 182167-02-8 Cat. No.: A1498391 Molecular Weight: 457.56

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM-652) inhibits estradiol (E2)-induced transcriptional activity of ERα (IC 50 = 2 nM) and ERβ (IC 50 = 0.4 nM). Acolbifene (EM-652) possesses potent and pure anticarcinogenic properties.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Product Properties

• ALogP: 5.2

Names and Identifiers

• Isomeric SMILES: CC1=C([C@@H](OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC=C(C=C5)O
• Molecular Weight: 457.56
• Reaxy-Rn: 7666136
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7666136&ln=

References

1. Chao Lu, Lingang Zhao, Liyuan Tian, Chenguang Lin, Lei Wu.  (2024)  Antidepressant advantage of Chaihushugan san in female mice: A novel signaling mechanism in hippocampus.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39053711] [10.1016/j.jep.2024.118627]