Alizarin(1,2-DHAQ) - Moligand™,10mM in DMSO , CAS No.72-48-0

CAS: 72-48-0 Cat. No.: A408093 Fórmula: C₁₄H₈O₄ Peso molecular: 240.21 Beilstein Registry Number: 1914037 Número CE: 200-782-5

GRAU & PUREZA Moligand™, 10mM in DMSO

Synonyms

Anthraquinonic | 1,​2-​dihydroxy-9,​10-​anthracenedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 andCYP1B1withIC50of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
In vitro

Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with K_i of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes.

In vivo

Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Especificações

Sinónimos

Anthraquinonic | 1,​2-​dihydroxy-9,​10-​anthracenedione

Especificações e pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Nomes e identificadores

SMILES isoméricas

C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3)O)O

WGK Alemanha

3

RTECS

CB6580000

Peso molecular

240.21

Beilstein

1914037

Reaxy-Rn

1914037

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1914037&ln=

Alvos associados (humanos)

CYP1B1 Tchem Cytochrome P450 1B1 (1 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro
• Ponto de ebulição (°C): 430°C
• Ponto de fusão (°C): 290°C