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APTO-253 - ≥98% , CAS No.916151-99-0

CAS: 916151-99-0 Cat. No.: A413688 Fórmula: C22H14FN5 Peso molecular: 367.38
COA
APTO-253 - ≥98% CAS No(916151-99-0) by Aladdin Scientific
Disponível para encomenda
GRADE & PURITY ≥98%
Synonyms
NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
USA
Alemanha (EU)*
Price
Qty
2mg
A413688-2mg
6 Em stock
—

23,90US$

35,90US$
Gravar 12,00 US$ (33.43%)
5mg
A413688-5mg
9 Em stock
—

50,90US$

76,90US$
Gravar 26,00 US$ (33.81%)
25mg
A413688-25mg
8 Em stock
—

189,90US$

284,90US$
Gravar 95,00 US$ (33.35%)
50mg
A413688-50mg
8 Em stock
—

317,90US$

476,90US$
Gravar 159,00 US$ (33.34%)
100mg
A413688-100mg
6 Em stock
—

572,90US$

859,90US$
Gravar 287,00 US$ (33.38%)
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Visão geral Specifications Propriedades do produto Nomes e identificadores Documentation Advanced Data Taxonomic Classification Estrutura 3D Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Calculadoras de soluções Revisões
🧪
Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Information

APTO-253 APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21) , promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4) .


Targets

c-Myc ; KLF4

Specifications

Sinónimos
NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan
Especificações e pureza
≥98%
Mecanismos bioquímicos e fisiológicos
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
Condições de armazenamento de armazenamento
Store at -20°C
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Pureza
≥98%
Propriedades do produto
ALogP
4.287
hba_count
3
Contagem HBD
2
Ligação rotativa
1
Nomes e identificadores
Pubchem Sid
488197814
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/488197814
Sorrisos canónicos
CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
IUPAC Name
2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
InChIKey
NIRXBXIPHUTNNI-UHFFFAOYSA-N
INCHI
1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
SMILES isoméricas
CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
Peso molecular
367.38
Reaxy-Rn
20465211
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20465211&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassePhenanthrolines
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPhenanthrolines
Alternative Parents Quinolines and derivatives  Indoles  Benzimidazoles  Substituted pyrroles  Pyridines and derivatives  Benzenoids  Aryl fluorides  Imidazoles  Heteroaromatic compounds  Azacyclic compounds  Organonitrogen compounds  Organofluorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 1,10-phenanthroline - Quinoline - Benzimidazole - Indole - Indole or derivatives - Aryl fluoride - Aryl halide - Benzenoid - Substituted pyrrole - Pyridine - Azole - Heteroaromatic compound - Imidazole - Pyrrole - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
DescriçãoThis compound belongs to the class of organic compounds known as phenanthrolines. These are aromatic polycyclic compounds containing the phenanthroline skeleton, which is a derivative of phenanthrene, and consists of two pyridine rings non-linearly joined by a benzene ring.
External Descriptors Not available
Estrutura 3D
Modelo de Estrutura Química Interativa





Alvos associados (não humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de ação
Certificados（CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDataItem
E2327762Certificate of AnalysisMar 11, 2026 A413688
E2327763Certificate of AnalysisMar 11, 2026 A413688
E2327765Certificate of AnalysisMar 11, 2026 A413688
E2327767Certificate of AnalysisMar 11, 2026 A413688
E2327768Certificate of AnalysisMar 11, 2026 A413688
E2327769Certificate of AnalysisMar 11, 2026 A413688
E2327770Certificate of AnalysisMar 11, 2026 A413688
E2327771Certificate of AnalysisMar 11, 2026 A413688
E2327772Certificate of AnalysisMar 11, 2026 A413688
E2327774Certificate of AnalysisMar 11, 2026 A413688
Propriedades químicas e físicas
SolubilidadeSolubility (25°C) In vitro DMSO: 73 mg/mL (198.7 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO (mg/mL) Solubilidade máxima73
DMSO (mM) Solubilidade máxima198.704338831727
Água (mg/mL) Solubilidade máxima＜1
Peso molecular367.400 g/mol
XLogP34.300
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass367.123 Da
Monoisotopic Mass367.123 Da
Topological Polar Surface Area70.300 Ų
Heavy Atom Count28
Formal Charge0
Complexity589.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluções
Revisões

Avaliações dos Clientes

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