ASN007 - 10mM in DMSO , Mitogen-activated protein kinase; ERK1/ERK2 inhibitor, CAS No.2055597-12-9, Mitogen-activated protein kinase; ERK1/ERK2 inhibitor

CAS: 2055597-12-9 Cat. No.: A655415 Molecular Weight: 473.93 PubChem CID: 124122366

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK . ASN007 inhibits ERK1/2 with low single-digit nM IC 50 values. ASN007 can be used for the research of cancers driven by RAS mutations

In Vitro

ASN007 (ERK-IN-3) inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ASN007 (ERK-IN-3) (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:ERK1 ERK2

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK . ASN007 inhibits ERK1/2 with low single-digit nM IC 50 values. ASN007 can be used for the research of cancers driven by RAS mutations.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Mitogen-activated protein kinase; ERK1/ERK2 inhibitor

Product Properties

• ALogP: 2.3

Names and Identifiers

• Isomeric SMILES: CC1=CN=C(N=C1N2C=C(N=C2)C(=O)N[C@H](CN)C3=CC(=CC(=C3)Cl)F)NC4CCOCC4
• PubChem CID: 124122366
• MeSH Entry Terms: ASN007;ERK-IN-3;N-((1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl)imidazole-4-carboxamide
• Molecular Weight: 473.93