10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
In vitro
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | COC1=C(C=C2C(=C1O)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC2=O)O |
|---|---|
| Molecular Weight | 328.28 |
| Reaxy-Rn | 1354737 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1354737&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Melt Point(°C) | 238°C |
|---|
| 1. Huang Dan, Sun Chaoqun, Chen Min, Bai Shuyou, Zhao Xuanna, Wang Weiming, Geng Kang, Huang Wenbo, Zhao Tingting, Wu Bin, Zhang Guilin, Wu Dong, Xu Youhua. (2022) Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway. Frontiers in Pharmacology, [PMID:36313381] [10.3389/fphar.2022.994878] |
| 2. Yinggui Zhu, Lili Zou, Qin Dong, Derong Jiang. (2015) Determination of bergenin based on the electrochemiluminescence quenching of tris(2,2′-bipyridine)-ruthenium(II). LUMINESCENCE, 30 (8): (1269-1273). [PMID:25808319] [10.1002/bio.2891] |
| 3. Min Chen, Cuifen Chen, Yun Gao, Dongming Li, Dan Huang, Ziyu Chen, Xuanna Zhao, Qiu Huang, Dong Wu, Tianwen Lai, Guomei Su, Bin Wu, Beixian Zhou. (2020) Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway. PULMONARY PHARMACOLOGY & THERAPEUTICS, [PMID:32615160] [10.1016/j.pupt.2020.101921] |
| 4. Yanrong Zhu, Lichen Yao, Yilei Guo, Jing Zhang, Yufeng Xia, Zhifeng Wei, Yue Dai. (2024) Bergenin attenuates triptolide-caused premature ovarian failure in mice based on the antioxidant activity. REPRODUCTIVE TOXICOLOGY, [PMID:38735593] [10.1016/j.reprotox.2024.108608] |
| 5. Yu-Zhen Zhang, Yi-Le Li, Zhi Jin, Mao-Fang He, Yi-Mei Tang, Jian Zhang, Bo Zhang. (2024) Fabrication of molecularly imprinted polymers based on magnetic covalent organic framework for highly selective and sensitive analysis of genistein in F. Philippinensis. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.110013] |
| 6. Yao Sun, Shihao Cai, Hongting Liu, Conglu Zhao, Xiang Xu, Xiaoting Wang, Jia Zhang, Chaoyue Zheng, Keran Li, Shouchun Peng, Honggang Zhou, Aiguo Xu, Xiaoting Gu, Xiaoyu Ai, Cheng Yang. (2025) Bergenin and vitexin delivery platform using mouse lung fibroblasts-derived exosomes for bleomycin-induced pulmonary fibrosis therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:40456424] [10.1016/j.ijpharm.2025.125750] |
