BIO-013077-01 - ≥98% , CAS No.746667-48-1

CAS: 746667-48-1 Cat. No.: B650439 Fórmula: C₁₇H₁₃N₅ Peso molecular: 287.32 Número CE: 110-524-2 PubChem CID: 10469294

GRADE & PURITY ≥98%

Synonyms

HY-118810 | BIO-013077-01 | SCHEMBL4008166 | BCP30129 | MS-24106 | AKOS016013184 | 6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline | 6-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline | ZB0034 | EX-A3237 | AJ-97166;AJ97166;AJ 97166;6-[5-(6-me

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

BIO-013077-01 is a pyrazole TGF-β inhibitor.

In Vitro

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinónimos

HY-118810 | BIO-013077-01 | SCHEMBL4008166 | BCP30129 | MS-24106 | AKOS016013184 | 6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline | 6-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline | ZB0034 | EX-A3237 | AJ-97166;AJ97166;AJ 97166;6-[5-(6-me

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

BIO-013077-01 is a pyrazole TGF-β inhibitor.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC4=NC=CN=C4C=C3

IUPAC Name

6-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline

InChIKey

VXJLYXCHOKEODY-UHFFFAOYSA-N

INCHI

1S/C17H13N5/c1-11-3-2-4-15(21-11)17-13(10-20-22-17)12-5-6-14-16(9-12)19-8-7-18-14/h2-10H,1H3,(H,20,22)

SMILES isoméricas

CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC4=NC=CN=C4C=C3

CAS alternativo

746667-48-1

PubChem CID

10469294

Peso molecular

287.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoxalines
• Alternative Parents: Methylpyridines Pyrazines Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoxaline - Methylpyridine - Benzenoid - Pyridine - Pyrazine - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (348.04 mM; Need ultrasonic)
• Peso molecular: 287.320 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 287.117 Da
• Monoisotopic Mass: 287.117 Da
• Topological Polar Surface Area: 67.400 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 376.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1