BMS-358233 , CAS No.601519-75-9

CAS: 601519-75-9 Cat. No.: B1427787 Fórmula: C₂₅H₂₅ClN₆O₂S Peso molecular: 509.02

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PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers.

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Nomes e identificadores

Peso molecular

509.02